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Adipogen/MBIMPH F-Analog 2/AG-CR1-3909-M001/1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/MBIMPH F-Analog 2/AG-CR1-3909-M001/1 mg

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ProductDetails
SynonymsMBIMPHFluorinatedAnalog2;4-((6-Fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-N-hydroxybenzamide
ProductTypeChemical
Properties
FormulaC16H14FN3O2
MW299.3
PurityChemicals≥95%(HPLC)
AppearanceLightbrownsolid.
SolubilitySolubleinDMSO,ethanolormethanol.
IdentityDeterminedby1H-NMR.
InChiKeyQFZFFNKSKDGHQP-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceKeepcoolanddry.
Protectfromlight.
Use/StABIlityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
  • Cellpermeable,potentandselectiveclassIIbHDAC6inhibitor(IC50=5nM).DisplayshighselectivityoverallotherHDACs(IC50=0.2-11µM).
  • Inducescellularα-tubulin,butnothistoneH3hyperacetylationinNeuro-2acells.Promotesmitochondrialtransport.
  • ShowsimprovedkineticsandbiochemicalpotencyagainstHDAC6comparedtotubastatinA(AG-CR1-3900).
  • HDAC6deacetylatestubulin,HSP90andthecorehistones(H2A,H2B,H3,H4).Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.HDAC6playsanimportantroleinmicrotubule-dependentcellmotility,transcriptionalregulation,degradationofmisfoldedproteinsandcellcycleandisinvolvedinautophagy,inflammation,cancerandneurodegeneration.
ProductReferences
  1. Bicyclic-cappedhistonedeacetylase6inhibitorswithimprovedactivityinamodelofaxonalcharcot-marie-toothdisease:S.Shen,etal.;ACSChemicalNeuroscience(submitted)(2015)
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