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Adipogen/Nucleobindin-2 (mouse) (rec.)/AG-40A-0074-C050/50 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/Nucleobindin-2 (mouse) (rec.)/AG-40A-0074-C050/50 µg

MoreInformation
ProductDetails
SynonymsDNA-bindingProteinNEFA;Prepronesfatin;Nucb2;Nesfatin
ProductTypeProtein
Properties
Source/HostE.coli
SequenceMousenucleobindin-2(aa25-420)isfusedattheC-terminustoaHis-tag.
CrossreactivityMouse
MW~55kDa(SDS-PAGE)
Purity≥90%(SDS-PAGE)
EndotoxinContent<1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).="">
FormulationLiquid.0.2μm-filteredsolutioninPBS,pH7.2.
OtherProductDataUniProtlinkP81117:Nucleobindin-2(mouse)[Precursor]
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceAfteropening,preparealiquotsandstoreat-20°C.
Avoidfreeze/thawcycles.
Use/StABIlityStableforatleast6monthsafterreceiptwhenstoredat-20°C.
Workingaliquotsarestableforupto3monthswhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
Nucleobindin-2(NUCB2;Prepronesfatin)wasfirstisolatedinADIpocytes,butisalsoexpressedbygastricmucosaandpancreaticβcells.Thispatternofnucleobindin-2expression,aswellasthepresenceofnucleobindin-2withintheplasmaofrodentsandhumans,stronglysuggeststhatthiscompoundmayactasacirculatingregulatoryfactor.NUCB2canbecleavedintothreepolypeptides:nesfatin-1,nesfatin-2,andnesfatin-3.Anorexigeniceffectshavebeendescribedfornesfatin-1thatplaysanimportantroleinhypothalamicpathwaysregulatingfoodintakeandenergyhomeostasisandactinginaleptin-independentmanner.Nesfatin-1mayalsoexerthypertensiverolesandmodulatebloodpressurethroughdirectlyactingonperipheralarterialresistance.Nucleobindin-2isthereforereportedtoreducefoodintakeafteradmiNISTration,mostlyreferingtothecleavedpeptidenesfatin-1.Excessnucleobindin-2/nesfatin-1inthebrainleadstoalossofappetite,lackoftheproteininthebrainleadstoanincreaseofappetite.
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