Adipogen/Luteolin/AGCN20098M005/5 mg

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ProductDetails
Synonyms	3,4,5,7-Tetrahydroxyflavone;Luteolol;BRN0292084;C.I.NaturalYellow2;Digitoflavone;Flacitran;Flavopurpol;Daphneflavonol;Argemexitin
ProductType	Chemical
Properties
Formula	C₁₅H₁₀O₆
MW	286.2
CAS	491-70-3
RTECS	LK9275210
Source/HostChemicals	Synthetic.
PurityChemicals	≥98%(HPLC)
Appearance	Yellowsolid.
Solubility	SolubleinDMSO,DMF,methanolorethanol.Slightlysolubleinwater.
InChiKey	IQPNAANSBPBGFQ-UHFFFAOYSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
Use/StABIlity	Stableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Anticancerandantimetastatic[1,3,8].
α-Glucosidaseinhibitor[2].
TopoisomeraseIInhibitor[3].
Apoptosisinducer[7,8].
Anti-inflammatory[4,5].
15-Lipoxygenase(15-LOX)inhibitor[6].
IL-6productioninhibitor[9].
Fattyacidsynthase(FAS)inhibitor[10].
Antioxidant.FreerADIcalscavenger[11].
AntiAdipogenic.PPAR-γinhibitor[12].
Neuroprotective.Monoaminetransporteractivator[13].
Inhibitorofphosphodiesterases1-5(PDE1-5)[14].
PKC(ε)andSrckinaseinhibitor[15].
HDACinhibitor[16].
Autophagymodulator[17]
Phosphatidylinositol3-kinase(PI3K)/Aktsignalinginhibitor[18].
p90ribosomalS6kinase(RSK1/RSK2)kinaseactivityinhibitor[19].

ProductReferences

Effectsofluteolinandquercetin,inhibitorsoftyrosinekinase,oncellgrowthandmetastasis-associatedpropertiesinA431cellsoverexpressingepidermalgrowthfactorreceptor:Y.T.Huang,etal.;Br.J.Pharmacol.128,999(1999)
Inhibitionofalpha-glucosidaseandamylasebyluteolin,aflavonoid:J.S.Kim,etal.;Biosci.Biotechnol.Biochem.64,2458(2000)
Luteolin,anemerginganti-cancerflavonoid,poisonseukaryoticDNAtopoisomeraseI:A.R.Chowdhury,etal.;Biochem.J.366,653(2002)
Inhibitionofmatrix-proteasesbypolyphenols:Chemicalinsightsforanti-inflammatoryandanti-invasiondrugdesign:L.Sartor,etal.;Biochem.Pharmacol.64, 229(2002)
Luteolininhibitsthenuclearfactor-kappaBtranscriptionalactivityinRat-1fibroblasts:S.H.Kim,etal.;Biochem.Pharmacol.66,955(2003)
Inhibitionof15-lipoxygenasesbyflavonoids:Structure-activityrelationsandmodeofaction:C.D.Sadik,etal.;Biochem.Pharmacol.65,773(2003)
InductionofapoptosisbyluteolinthroughcleavageofBcl-2familyinhumanleukemiaHL-60cells:A.C.Cheng,etal.;Eur.J.Pharmacol.509,1(2005)
Luteolininhibitsinsulin-likegrowthfactor1receptorsignalinginprostatecancercells:J.Fang,etal.;Carcinogenesis28,713(2007)
LuteolinreducesIL-6productioninmicrogliabyinhibitingJNKphosphorylationandactivationofAP-1:S.Jang,etal.;PNAS105,7534(2008)
Inhibitionoffattyacidsynthasebyluteolinpost-transcriptionallydown-regulatesc-Metexpressionindependentofproteosomal/lysosomaldegradation:D.T.Coleman,etal.;Mol.CancerTher.8,214(2009)
Physicochemicalpropertiesandantioxidantactivitiesofluteolin-phospholipidcomplex:K.Xu,etal.;Molecules14,3486(2009)
LuteolininhibitsadipogenicdifferentiationbyregulatingPPARgammaactivation:H.S.Park,etal.;Biofactors35,373(2009)
FunctionalactivationofmonoaminetransportersbyluteolinandapigeninisolatedfromthefruitofPerillafrutescens:G.Zhao,etal.;NeuRochem.Int.56,168(2010)
Luteolin,anon-selectivecompetitiveinhibitorofphosphodiesterases1-5,displaced[3H]-rolipramfromhigh-affinityroliprambindingsitesandreversedxylazine/ketamine-inducedanesthesia:M.C.Yu,etal.;Pulmon.Gastrointest.Urogen.Pharmacol.627,269(2010)
LuteolininhibitsproteinkinaseC(epsilon)andc-SrcactivitiesandUVB-inducedskincancer:S.Byun,etal.;CancerRes.70,2415(2010)
Inhibitionofcellsurvival,invasion,tumorgrowthandhistonedeacetylaseactivitybythedietaryflavonoidluteolininhumanepithelioidcancercells:S.Attoub,etal.;Eur.J.Pharmacol.651,18(2011)
Autophagyinhibitorchloroquineenhancedthecelldeathinducingeffectoftheflavonoidluteolininmetastaticsquamouscellcarcinomacells:L.Verschooten,etal.;PLoSOne7,e48264
RafandPI3Karethemoleculartargetsfortheanti-metastaticeffectofLuteolin:H.Y.Kim,etal.;Phytother.Res.27,1481(2013)
Luteolinisanovelp90ribosomalS6kinase(RSK)inhibitorthatsuppressesNotch4signalingbyblockingtheactivationofY-boxbindingprotein-1(YB-1):K.M.Reipas,etal.;Oncotarget4,329(2013)

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Adipogen/Luteolin/AGCN20098M005/5 mg