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Adipogen/IHR1/AGCR13526M001/1 mg
MoreInformation
ProductDetails
SynonymsInhibitorofHedgehogResponse1;N,N-1,4-Phenylenebis[2,5-dichloro-benzamide
ProductTypeChemical
Properties
FormulaC20H12Cl4N2O2
MW454.1
CAS548779-60-8
PurityChemicals≥98%(NMR)
AppearanceWhitetogreysolid.
SolubilitySolubleinDMSO.
IdentityDeterminedby1H-NMRandHR-MS.
InChiKeyVCLHHRGZKNUOAQ-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceProtectfromlight.
Use/StABIlityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
  • Sonichedgehog(Shh)signalingpathwayinhibitor.Potentialanticancercompound.
  • CellmembraneimpermeableSmoothened(Smo)antagoNIST.ActsonextracellularlyexposedSmoonly.
  • Bindstotheseven-transmembrane(7TM)pocket.Blockshedgehog-inducedmovementofSmointotheprimarycilium,disengagesSmo-dependentabrogationofGli2andGli3proteolyticprocessingandinhibitsGliactivityinducedbylossofPTCH1.
ProductReferences
  1. TheHedgehogpathwayeffectorsmoothenedexhibitssignalingcompetencyintheabsenceofciliaryaccumulation:C.W.Fan,etal.;Chem.Biol.21,1680(2014)

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