LC Labs/D3197 Dorsomorphin, Free Base, >99%/D3197/5 mg

• Dorsomorphin,alsoknownascompoundC,isapotent,reversible,ATP-competitiveAMP-activatedproteinkinase(AMPK)inhibitorwithKiof109nMintheabsenceofAMP.Zhou,G.,etal."RoleofAMP-activatedproteinkinaseinmechanismofmetforminaction."J.Clin.Invest.108:1167-1174(2001).
• Thisresearchcompoundisthefreebaseformofdorsomorphin.Wealsoplantoofferthedihydrochloridesaltform,pleaseinquireforavailablity.
• Inhibitionofbonemorphogeneticprotein(BMP)signalingbydorsomorphinduringtheearlycriticalstageofdifferentiationofpluripotentembryonicstem(ES)cellspromotedthedevelopmentofthecardiomyocytelineage,butattheexpenseofreduceddifferentiationofendothelial,smoothmuscle,andhematopoieticcells.Hao,J.,etal."Dorsomorphin,aselectivesmallmoleculeinhibitorofBMPsignaling,promotescardiomyogenesisinembryonicstemcells."PLoSOne3:e2904(2008).
• Dorsomorphindisruptedzebrafishangiogenesis,butnotbyblockingbonemorphogenicprotein(BMP)signaling.Dorsomorphinalsoshowedsignificant"off-target"effectsagainstthevascularendothelialgrowthfactor(VEGF)pathway.Hao,J.,etal."Invivostructure-activityrelationshipstudyofdorsomorphinanaloguesidentifiesselectiveVEGFandBMPinhibitors."ACS.Chem.Biol.5:245-253(2010).
• DorsomorphinreducedphosphorylationlevelsofSMAD1/5/8incellsstimulatedbyBMP2,BMP4,BMP6,andBMP7selectively,andblockedBMP-,hemojuvelin-,andinterleukin6-mediatedhepcidingenetranscriptionandBMP-inducedosteogenicdifferentiation.Italsoinhibitedhepcidintranscriptioniniron-stimulatedzebrafishandinducedhyperferremiainiron-repletemice.Yu,P.B.,etal."DorsomorphininhibitsBMPsignalsrequiredforembryogenesisandironmetabolism."Nat.Chem.Biol.4:33-41(2008).
• Theadditionofdorsomorphintotheculturemediumbeforetreatmentwithdifferentiationinducersreducedlipidaccumulationin3T3-L1cells.Suenaga,M.,etal."BMPInhibitionwithdorsomorphinlimitsadipogenicpotentialofpreadipocytes."J.Vet.Med.Sci.72:373-377(2010).
• DorsomorphintreatmentofMCF7breastcarcinomacellsledtoBaxredistributionfromthecytoplasmtomitochondriaandcausedapoptosisatleastpartlybyceramideupregulation,andprobablynotbyAMPKinhibition.Jin,J.,etal."AMPKinhibitorCompoundCstimulatesceramideproductionandpromotesBaxredistributionandapoptosisinMCF7breastcarcinomacells."J.LipidRes.50:2389-2397(2009).
• Insulindidnotaffectglucosetransportincontrolcellsbutincreasedglucoseuptakeforserum-starvedcellsthatwaspreventablebydorsomorphin.Ching,J.K.,etal."AroleforAMPKinincreasedinsulinactionafterserumstarvation."Am.J.Physiol.CellPhysiol.299:C1171-C1179(2010).
• Dorsomorphininhibitedthegrowthoffourcolorectalcancercelllines,causedG2/Marrest,andinducedapoptoticorautophagicdeath.Yang,W.L.,etal."AMPKinhibitorcompoundCsuppressescellproliferationbyinductionofapoptosisandautophagyinhumancolorectalcancercells."J.Surg.Oncol.106:680-688(2012).
• Thisdorsomorphinproductisthefreebaseform,whoseCASnumberisgivenabove.TheCASnumberofthedihydrochloridesaltformis1219168-18-9.
• Soldforlaboratoryormanufacturingpurposesonly;notforhuman,veterinary,food,orhouseholduse.
• ThisproductisofferedforR&Duseinaccordancewith(i)35USC271(e)+A13(1)intheU.S.;(ii)Section69.1ofJapanesePatentLawinJapan;(iii)Section11,No.2oftheGermanPatentActof1981inGermany;(iv)Section60,Paragraph5boftheU.K.PatentsActof1977intheU.K.;(v)Sections55.2(1)and55.2(6)andothercommonlawexemptionsofCanadianpatentlaw;(vi)Section68BofthePatentsActof1953inNewZealandtogetherwiththeamendmentofsamebytheStatutesAmendmentBillof2002;(vii)suchrelatedlegislationand/orcaselawasmaybeorbecomeapplicableintheaforementionedcountries;and(viii)suchsimilarlawsandrulesasmayapplyinvariousothercountries.
• Notavailableinsomecountries;notavailabletosomeinstitutions;notavailableforsomeuses.

Storage

Solubility

Disposal