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Adipogen/USP18 (mouse) (rec.) (His)/AG40T0563C050/50 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/USP18 (mouse) (rec.) (His)/AG40T0563C050/50 µg

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ProductDetails
SynonymsUbiquitin-likeCarboxyl-terminalHydrolase18;ISG15-specificProtease;Ublthioesterase18
ProductTypeProtein
Properties
Source/HostE.coli
SequenceRecombinantmouseUSP18(aa47-368)(AccessionNr.Q9WTV6)fusedtoN-terminalHis-tag.
CrossreactivityMouse
MW~38kDa
Purity≥98%(SDS-PAGE)
FormulationLiquid.In50mMHEPES,pH7.5,100mMNaCl,10%glyceroland1mMTCEP.
OtherProductDataUse:Reactionconditionswillneedtobeoptimizedforeachspecificapplication.WerecommendaninitialrecombinantmouseUSP18concentrationof100-250nMwhenusingISG15-AMC(AG-40T-0274MC)asasubstrate.
DeclarationManufacturedbyBostonBiochem
ShippingandHandling
ShippingDRYICE
ShortTermStorage-20°C
LongTermStorage-80°C
HandlingAdviceAliquottoavoidfreeze/thawcycles.
Use/StabilityStableforatleast1yearafterreceiptwhenstoredat-80°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
USP18playsanimportantroleinantiviralresponsesandinterferon-mediatedsignalingpathways.Micelackingthegenearehypersensitivetointerferon,haveshortenedlifespansandpathologicabnormalitiesofthebrain.WhileitwasinitiallyspeculatedthatthecauseofthedefectsresultedfromtheaccumulationofISG15-conjugatedintracellularproteins(atargetofUSP18catalyticfunction),itwaslaterdemonstratedthatUSP18hasmultiplesignalingroles,atleastoneofwhichisindependentofitsISGylaseactivity.

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