Adipogen/(S)3Hydroxybutyric acid/AGCR13617M100/100 mg

MoreInformation
ProductDetails
Synonyms	(S)-β-Hydroxybutyricacid;L-(+)-3-Hydroxybutyricacid;L-(+)-BHB
ProductType	Chemical
Properties
Formula	C₄H₈O₃
MW	104.1
MerckIndex	14:4816
CAS	6168-83-8
PurityChemicals	≥98%(TLC)
Appearance	Whitesolid.
Solubility	Solubleinwater,100%ethanolormethanol.
Identity	Determinedby¹H-NMR.
OtherProductData	OpticalRotation:[α]20/Dc=6inH₂O:25°±1.0°
InChiKey	WHBMMWSBFZVSSR-VKHMYHEASA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
HandlingAdvice	Keepcoolanddry.
Use/Stability	Stableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Physiologicallyinsignificantstereoisomerof(R)-3-Hydroxybutyricacid,akeymetaboliteoftheketolyticpathway.
Anticonvulsant.
Endogenousinhibitorofhistonedeacetylases(HDACs)1,3and4.
Ligandoffreefattyacidreceptor3(FFAR3;GPR41)andhydroxycarboxylicacidreceptor2(HCAR2;GPR109B).
NLRP3inflammasomeinhibitor.PreventsK⁺-effluxandreducesASColigomerizationandspeckformation.

ProductReferences

Effectsofbeta-hydroxybutyricacidoninsulinbindingtoitsreceptorandonautophosphorylationofthereceptor:H.Ohtusaka,etal.;Endocrinol.Jpn.37,915(1990)
Acetoacetate,acetone,anddibenzylamine(acontaminantinL-(+)-beta-hydroxybutyrate)exhibitdirectanticonvulsantactionsinvivo:J.M.Rho,etal.;Epilepsia43,358(2002)
Thedirectmeasurementof3-beta-hydroxybutyrateenhancesthemanagementofdiabeticketoacidosisinchildrenandreducestimeandcostsoftreatment:M.Vanelli,etal.;DiabetesNutr.Metab.16,312(2003)
Detectionofcerebral{beta}-hydroxybutyrate,acetoacetate,andlactateonprotonMRspectroscopyinchildrenwithdiabeticketoacidosis:S.L.Wootton-Gorges,etal.;AJNR26,1286(2005)
β-HydroxybutyrateactivatestheNF-κBsignalingpathwaytopromotetheexpressionofpro-inflammatoryfactorsincalfhepatocytes:X.Shi,etal.;Cell.Physiol.Biochem.33,920(2014)
β-hydroxybutyrate:Muchmorethanametabolite:J.C.Newman&E.Verdin;Diab.Res.Clin.Pract.106,173(2014)(Review)
BHBAsuppressesLPS-inducedinflammationinBV-2cellsbyinhibitingNF-κBactivation:S.P.Fu,etal.;Med.Inflamm.2014,ID983401(2014)
Anti-inflammatoryeffectsofBHBAinbothinvivoandinvitroParkinsonsdiseasemodelsaremediatedbyGPR109A-dependentmechanisms:S.P.Fu,etal.;J.Neuroinflamm.12,ID9(2015)
Theketonemetaboliteβ-hydroxybutyrateblocksNLRP3inflammasome-mediatedinflammatorydisease:Y.H.Youm,etal.;Nat.Med.21,263(2015)
Tamingtheinflammasome:M.Levy,etal.;Nat.Med.21,213(2015)
Inflammasomeinhibition:puttingoutthefire:M.G.Netea&L.A.Joosten;CellMetab.21,513(2015)
Inflammasome:starvinginflammation:E.Kugleberg;Nat.Rev.Immunol.15,199(2015)(Review)
TheNlrp3inflammasomeadmitsdefeat:C.J.Gross&O.Gross;TrendsImmunol.36,323(2015)(Review)

对照品标准品，生物试剂盒，gibco胎牛血清，试剂采购网，中国试剂网，细胞因子试剂盒

Adipogen/(S)3Hydroxybutyric acid/AGCR13617M100/100 mg