Adipogen/Pyripyropene A/AGCN20106M001/1 mg

MoreInformation
ProductDetails
Synonyms	(+)-PyripyropeneA;PPPA;FO1289A
ProductType	Chemical
Properties
Formula	C₃₁H₃₇NO₁₀
MW	583.6
CAS	147444-03-9
Source/HostChemicals	IsolatedfromAspergillusfumigatusFO-1289.
PurityChemicals	≥95%(HPLC)
Appearance	Palepinktorustybrownsolid.
Solubility	Solubleinmethanol,chloroform,ethylacetateorDMSO.Insolubleinwaterorhexane.
Declaration	ManufacturedbyBioLinksK.K.withcourtesystrainfromTheKitasatoInstitute.
InChiKey	PMMQOFWSZRQWEV-RVTXXDJVSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
Use/Stability	Stableforatleast3yearsafterreceiptwhenstoredat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Antibiotic[1].
Highlyspecificinhibitorofacyl-coenzymeA:cholesterolacetyltransferase2(ACAT2)[1-6,8,9].
Anti-angiogenic[10].
Antiatherogenicandantiatheroscleroticagent.Showscholesterol-loweringandatheroprotectiveactivities.[7,11,12].

ProductReferences

Pyripyropenes,highlypotentinhibitorsofacyl-CoA:cholesterolacyltransferaseproducedbyAspergillusfumigatus:S.Omura,etal.;J.Antibiot.(Tokyo)46,1168(1993)
Pyripyropenes,novelinhibitorsofacyl-CoA:cholesterolacyltransferaseproducedbyAspergillusfumigatus.II.StructureelucidationofpyripyropenesA,B,CandD:Y.K.Kim,etal.;J.Antibiot.(Tokyo)47,154(1994)
Pyripyropenes,novelinhibitorsofacyl-CoA:cholesterolacyltransferaseproducedbyAspergillusfumigatus.I.Production,isolation,andbiologicalproperties:H.Tomoda,etal.;J.Antibiot.(Tokyo)47,148(1994)
Mass-productionofhumanACAT-1andACAT-2toscreenisoform-specificinhibitor:adifferentsubstratespecificityandinhibitoryregulation:K.H.Cho,etal.;BBRC309,864(2003)
IdentificationofACAT1-andACAT2-specificinhibitorsusinganovel,cell-basedfluorescenceassay:individualACATuniqueness:A.T.Lada,etal.;J.LipidRes.45,378(2004)
Selectivityofmicrobialacyl-CoA:cholesterolacyltransferaseinhibitorstowardisozymes:T.Ohshiro,etal.;J.Antibiot.(Tokyo)60,43(2007)
Potentialtherapeuticsforobesityandatherosclerosis:inhibitorsofneutrallipidmetabolismfrommicroorganisms:H.Tomoda&S.Omura;Pharmacol.Ther.115,375(2007)(Review)
Identificationoftheinteractionsitewithinacyl-CoA:cholesterolacyltransferase2fortheisoform-specificinhibitorpyripyropeneA:A.Das,etal.;J.Biol.Chem.283,10453(2008)
Selectivityofpyripyropenederivativesininhibitiontowardacyl-CoA:cholesterolacyltransferase2isozyme:T.Ohshiro,etal.;J.Antibiot.(Tokyo).61,503(2008)
Pyripyropenes,fungalsesquiterpenesconjugatedwithalpha-pyroneandpyridinemoieties,exhibitsanti-angiogenicactivityagainsthumanumbilicalveinendothelialcells:A.Hayashi,etal.;Biol.Pharm.Bull.32,1261(2009)
PyripyropeneA,anacyl-coenzymeA:cholesterolacyltransferase2-selectiveinhibitor,attenuateshypercholesterolemiaandatherosclerosisinmurinemodelsofhyperlipidemia:T.Ohshiro,etal.;Arterioscler.Thromb.Vasc.Biol.31,1108(2011)
Isoform-specificinhibitorsofACATs:recentadvancesandpromisingdevelopments:T.Ohshiro&H.Tomoda;FutureMed.Chem.3,2039(2011)(Review)

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Adipogen/Pyripyropene A/AGCN20106M001/1 mg