Description
9-cisRetinoicacidisanagonistatretinoicacidreceptors(RARs)andretinoicXreceptors(RXRs);itexhibitscardioprotective,neuroprotective,pro-angiogenic,anti-inflammatory,andanticancerchemotherapeuticactivities.ThiscompoundisaderivativeofvitaminA.9-cisRetinoicacidpreventshypoxia-induceddecreasesinthemitochondrialmembranepotentialandtheinductionofapoptosisandcelldeathincardiomyocytes.Invivo,thiscompoundpreventsmethamphetamine-inducedchangesinlocomotoractivityandtyrosinehydroxylaseexpressionandincreaselevelsofbonemorphogeneticprotein7(BMP7).Additionally,9-cisretinoicaciddecreases6-OHDA-inducedneuronaldeathinanimalmodelsofParkinson’sdisease.Inmonocytes,9-cisretinoicaciddecreasesLPS-stimulatedexpressionofIL-6,TNF-α,CCL3,andCCL4.Incellularandanimalmodelsofadrenocorticalcancer,thiscompounddecreasescellviabilityandtumorgrowth.9-cisRetinoicacidalsoinhibitsadipogenesis.Inlymphaticendothelialcells,9-cisretinoicacidincreasescellproliferation,migration,andtubeformation.