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Adipogen/EGF (human):Fc (human) (rec.)/CHIHF210EGFC100/100 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/EGF (human):Fc (human) (rec.)/CHIHF210EGFC100/100 µg

MoreInformation
ProductDetails
SynonymsPro-EpidermalGrowthFactor
ProductTypeProtein
Properties
Source/HostCHOcells
SequenceTheextracellulardomainofhumanEGF(aa971-1023)isfusedtotheN-terminusoftheFcregionofhumanIgG1.
CrossreactivityHuman
Purity≥98%(SDS-PAGE)
EndotoxinContent<0.06eu mu;g="" protein="" (lal="" test;="" lonza).="">
ReconstitutionReconstitutewith100µlsterilewater.
Add1XPBStothedesiredproteinconcentration.
FormulationLyophilizedfrom0.2μm-filteredsolutioninPBS.
OtherProductDataNCBIreferenceNP_001954.2:EGF(human)
DeclarationManufacturedbyChimerigen.
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceAvoidfreeze/thawcycles.
Use/StabilityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Workingaliquotsarestableforupto3monthswhenstoredat-20°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
Epidermalgrowthfactor(EGF)isagrowthfactorandthefoundingmemberoftheEGFfamily.AllEGFfamilymembersaresynthesizedastypeItransmembraneprecursorproteinsthatmaycontainseveralEGFdomainsintheextracellularregion.Thematureproteinsarereleasedfromthecellsurfacebyregulatedproteolysis.EGFispresentinvariousbodyfluids,includingblood,milk,urine,saliva,seminalfluid,pancreaticjuice,cerebrospinalfluid,andamnioticfluid.FourErbB(HER)familyreceptortyrosinekinasesincludingEGFR/ErbB1,ErbB2,ErbB3andErbB4,mediateresponsestoEGFfamilymembers.ThesereceptorsundergoacomplexpatternofligandinducedhomoorheterodimerizationtotransduceEGFfamilysignals.EGFbindstothereceptorEGFRstimulatingtheintrinsicprotein-tyrosinekinaseactivityofthereceptor.Thetyrosinekinaseactivityinitiatesasignaltransductioncascadethatresultsinavarietyofbiochemicalchangeswithinthecell,includingariseinintracellularcalciumlevels,increasedglycolysisandproteinsynthesis,andincreasesintheexpressionofcertaingenesincludingthegeneforEGFR,whichleadtoDNAsynthesis,cellgrowth,proliferationanddifferentiation.OtherbiologicalactivitiesascribedtoEGFincludeepithelialdevelopment,angiogenesis,inhibitionofgastricacidsecretion,fibroblastproliferation,andcolonyformationofepidermalcellsinculture.DefectsinEGFarethecauseofhypomagnesemiatype4(HOMG4),alsoknownasrenalhypomagnesemianormocalciuric.HOMG4isadisordercharacterizedbymassiverenalhypomagnesemiaandnormallevelsofserumcalciumandcalciumexcretion.Clinicalfeaturesincludeseizures,mild-tomederatepsychomotorretardation,andbrisktendonreflexes.

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