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Adipogen/antiPyk2 (RAFTK), pAb/YIFLFPA0080/100 µl188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/antiPyk2 (RAFTK), pAb/YIFLFPA0080/100 µl

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ProductDetails
SynonymsCAKB;FAK2;CADTK;PTK2B;RAFTK;FADK2;CAK-β;EC=2.7.10.2;FocalAdhesionKinase2;CellAdhesionKinaseβ;Protein-TyrosineKinase2-β;Proline-richTyrosineKinase2
ProductTypePolyclonalAntibody
Properties
Immunogen/AntigenSyntheticpeptide.
ApplicationWesternBlot(1:2,000)
CrossreactivityHuman
Mouse
Rat
PurityDetailAffinitypurification.
FormulationLiquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol.
OtherProductDataClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
DeclarationManufacturedbyAbFrontier
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StabilityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
Focaladhesionkinasesubfamilyconsistsofthenon-receptorproline-richproteintyrosinekinases(PTKs).Twomembersofthefamilyarefocaladhesionkinase(FAK)andproline-richtyrosinekinase2(PYK2).Thesetwokinaseshavemolecularmassbetween110-125kDaandarecloselyrelatedintheirstructure.Thepresenceoftwoproline-richmotifswithintheC-terminaldomainsisconserved.Pyk2isexpressedprimarilyinbrainandhematopoieticcellsandbecomesactivatedinresponsetostimulationthroughnumerousreceptors,includingintegrins,chemokinereceptors,andantigenreceptors.Itisalsoexpressedinbothinbone-formingosteoblastsandbone-resorbingosteoclasts,andthoughttohavepositiveroleinosteoblastmaturationandboneresorption.PhosphorylationofPyk2leadstotherecruitmentofSrcfamilykinasesandtheactivationofErks.Pyk2alsointeractswithandphosphorylatesthefocaladhesion-relatedprotein,paxillin,andothercytoskeletalproteins,suggestingitspivotalroleinvariouscellularevents.Involvedincalciuminducedregulationofionchannelandactivationofthemapkinasesignalingpathway.Mayrepresentanimportantsignalingintermediatebetweenneuropeptideactivatedreceptorsorneurotransmittersthatincreasecalciumfluxandthedownstreamsignalsthatregulateneuronalactivity.InteractswiththeSH2domainofGrb2.Mayphosphorylatethevoltage-gatedpotassiumchannelproteinKv1.2.Itsactivationishighlycorrelatedwiththestimulationofc-JunN-terminalkinaseactivity.Involvedinosmoticstress-dependentSNCATyr-125phosphorylation.
ProductReferences
1)BuckbinderL.etal.,(2007)ProcNatlAcadSciUSA.104:10619-10624.(General)
2)AvrahamH.etal.,(2000)CellSignal.12:123-133.(General)
3)SchlaepferD.D.etal.,(1999)ProgBiophysMolBiol.71:435-478.(General)

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