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Adipogen/antiTransglutaminase 2, mAb (14G2)/YIFLFMA0094/100 µl188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/antiTransglutaminase 2, mAb (14G2)/YIFLFMA0094/100 µl

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ProductDetails
SynonymsTGC;TGM2;TG(C);TGaseH;TGaseC;TGase-2;EC=2.3.2.13;TransglutaminaseH;TransglutaminaseC;Transglutaminase-2;TissueTransglutaminase;Protein-Glutamineγ-Glutamyltransferase2
ProductTypeMonoclonalAntibody
Properties
Clone14G2
IsotypeMouseIgG1κ
Immunogen/AntigenRecombinanthumanproteinpurifiedfromE.coli.
ApplicationELISA
WesternBlot(1:500)
Immunoprecipitation(1~2μl)
CrossreactivityHuman
PurityDetailAmmoniumsulfateprecipitation.
FormulationLiquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol.
OtherProductDataClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
DeclarationManufacturedbyAbFrontier
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StabilityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
Transglutaminase(TGase)catalysesthecrosslinkofproteinsbyformingε-(γ-glutamyl)lysineisopeptidebondsandrequiresthebindingofCa2+foritsactivity.Inmammals,eightdistinctTGaseisoenzymeshavebeenidentified.Tissuetransglutaminase(tTGase),alsoknownasTGase2,hasfourdistinctdomains:N-terminalβ-sandwich,catalyticcoreandtwoC-terminalβ-barreldomains.tTGasemayhavearoleincelldeath,cellproliferation,celldifferentiation,andreceptor-mediatedendocytosis.IntheAlzheimer’sdiseasebrain,theelevatedtTGaseactivityismanifestedbypolymerizationofanumberofproteins,includingAβpeptide,β-amyloidprecursorproteinandthetauprotein,withformationofneurofibrillarytangles.Catalyzesthecross-linkingofproteinsandtheconjugationofpolyaminestoproteins.
ProductReferences
1)Griffin,M.etal.(2002)Biochem.J.368,377-396.(General)
2)Fesus,L.andPiacentini,M.(2002)Trends.Biochem.Sci.27(10),534-539.(General)
3)Kim,SY.etal.(2002)Neurochem.Int.40,85-103.(General)

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