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Adipogen/BAY 439006/AGCR10025M025/25 mg
MoreInformation
ProductDetails
SynonymsSorafenib;N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide
ProductTypeChemical
Properties
FormulaC21H16ClF3N4O3
MW464.8
CAS284461-73-0
PurityChemicals≥98%(NMR)
AppearanceWhitetooff-whitesolid.
SolubilitySolubleinDMSO,100%ethanol,methanolorethylacetate.
IdentityDeterminedby1H-NMR.
InChiKeyMLDQJTXFUGDVEO-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StabilityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
  • Antitumorcompound[1].
  • Broad-spectrumkinaseinhibitor[2].
  • Rafkinaseinhibitor[2,3].
  • Apoptosisinducer[3,4].
  • Cytostatic[5].
  • Angiogenesisinhibitor[2,5].
  • Review[6].
ProductReferences
  1. BAY43-9006:preclinicaldata:S.Wilhelm&D.S.Chien;Curr.Pharm.Des.8,2255(2002)
  2. Sorafenib(BAY43-9006,Nexavar),adual-actioninhibitorthattargetsRAF/MEK/ERKpathwayintumorcellsandtyrosinekinasesVEGFR/PDGFRintumorvasculature:L.Adnane,etal.;Meth.Enzymol.407,597(2005) 
  3. TheRafinhibitorBAY43-9006(Sorafenib)inducescaspase-independentapoptosisinmelanomacells:D.J.Panka,etal.;CancerRes.66,1611(2006) 
  4. ThekinaseinhibitorSorafenibinducescelldeaththroughaprocessinvolvinginductionofendoplasmicreticulumstress:M.Rahmani,etal.;Mol.Cell.Biol.27,5499(2007)
  5. BAY-43-9006Bayer/Onyx:J.T.Lee&J.A.McCubrey;Curr.Opin.Investig.Drugs4,757(2003)
  6. Sorafenib(BAY43-9006):reviewofclinicaldevelopment:R.Ng&E.X.Chen;Curr.Clin.Pharmacol.1,223(2006)

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