Adipogen/Ionomycin (free acid)/AGCN20416M005/5 mg

MoreInformation
ProductDetails
Synonyms	AntibioticSQ23377;EM94
ProductType	Chemical
Properties
Formula	C₄₁H₇₂O₉
MW	709.0
CAS	56092-81-0
RTECS	NO0600000
Source/HostChemicals	IsolatedfromStreptomycesconglobatus.
PurityChemicals	≥98%(HPLC,TLC)
Appearance	Waxyyellowtocolorlesssolid.
Solubility	SolubleinmethanolorDMSO.
InChiKey	PGHMRUGBZOYCAA-ZRDXXTDTSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
HandlingAdvice	Keepcoolanddry. Keepunderinertgas. Protectfromlight.
Use/Stability	Stableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Antibiotic[1].
PotentandhighlyselectiveCa²⁺ionophore.CommonlyusedtomodifyintracellularcalciumlevelstostudycalciumtransportacrossbiologicalmembranesandtocalibratefluorescentCa²⁺indicators[2,3].
IonomycinalsotransportsPb²⁺andsomeotherdivalentcations,aswellasseverallanthanideseriestrivalentcationsatefficienciesthataregreaterthanorequaltothoseforCa²⁺[3,9].
Apoptosisinducer[4,7].InducesapoptoticneuronaldegenerationinembryoniccorticalneuronsandcellcyclearrestatG1phaseandinducescentraldemyelination[6].
Usedtostimulatetheintracellularproductionofthecytokines,interferon,perforin,IL-2andIL-4usuallyinconjunctionwithPMA[5,8].
ADAM10agonist[10].
PotentinducerofsheddingCXCL16[10].
TREK-1channelsinhibitor[11].
PPARγligandwithauniquebindingmode.Showseffectiveglucose-loweringactivityinamousemodelofdiabetes[12].

ProductReferences

Ionomycin,anewpolyetherantibiotic:W.C.Liu,etal.;J.Antibiot.31,815(1978)
Characterizationofionomycinasacalciumionophore:C.Liu&T.E.Hermann;J.Biol.Chem.253,5892(1978)
Cationtransportandspecificityofionomycin.ComparisonwithionophoreA23187inratlivermitochondria:R.F.Kauffman,etal.;J.Biol.Chem.255,2735(1980)
Ionophore-inducedapoptosis:roleofDNAfragmentationandcalciumfluxes:D.M.Ojcius,etal.;Exp.CellRes.197,43(1991)
Contrastingeffectoftransforminggrowthfactortypebeta1(TGF-beta1)onproliferationandinterleukin-2receptorexpressioninactivatedandrapidlycyclingimmature(CD3-CD4-CD8-)thymocytes:A.DupuydAngeac,etal.;J.Cell.Physiol.154,44(1993)
Ca2+ionophore-inducedapoptosisonculturedembryonicratcorticalneurons:N.Takei&Y.Endo;BrainRes.652,65(1994)
Differentialactivationofacalcium-dependentendonucleaseinhumanBlymphocytes.Roleinionomycin-inducedapoptosis:K.M.Aagaard-Tillery,etal.;J.Immunol.155,3297(1995)
FlowcytometricanalysisofintracellularIFN-γ,IL-4andIL-10inCD3+4+T-cellsfromratspleen:E.M.Caraher,etal.;J.Immunol.Methods244,29(2000)
TheionophorenigericintransportsPb2+withhighactivityandselectivity:acomparisontomonensinandionomycin:S.A.Hamidinia,etal.;Biochemistry43,15956(2004)
ConstitutiveexpressionandregulatedreleaseofthetransmembranechemokineCXCL16inhumanandmurineskin:F.Scholz,etal.;J.Invest.Dermatol.127,1444(2007)
Calcium-dependentinhibitionofadrenalTREK-1channelsbyangiotensinIIandionomycin:J.J.Enyeart,etal.;Am.J.Physiol.CellPhysiol.301,C619(2011)
Identificationoftheantibioticionomycinasanunexpectedperoxisomeproliferator-activatedreceptorγ(PPARγ)ligandwithauniquebindingmodeandeffectiveglucose-loweringactivityinamousemodelofdiabetes:W.Zheng,etal.;Diabetologia56,401(2013)

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Adipogen/Ionomycin (free acid)/AGCN20416M005/5 mg