Adipogen/Creatine . monohydrate/AGCR13679G025/25 g

More Information
Product Details
Synonyms	N-(Aminoiminomethyl)-N-methylglycine monohydrate
Product Type	Chemical
Properties
Formula	C₄H₉N₃O₂ . H₂O
MW	131.1 . 18.0
CAS	6020-87-7
RTECS	MB7706000
Purity Chemicals	≥98%
Appearance	White solid.
Solubility	Soluble in water (10mg/ml).
InChi Key	MEJYXFHCRXAUIL-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

A nitrogenous organic acid that occurs naturally in vertebrates. Can be acquired through dietary consumption or formed from L-arginine, glycine and L-methionine in a multi-step reaction that occurs in the kidney and liver.
High-energy reservoir for the rapid regeneration of ATP. Its main role is to facilitate recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue via the action of creatine kinase(s).
Supplementation is investigated for the use in myopathies and enhancement of sports performance, primarily by increasing muscle mass. It is also investigated as a treatment of neuromuscular diseases, where it may aid in neuroprotection and by improving the cellular bioenergetic state.
Antioxidant compound.
Thermogenesis enhancer in beige adipocytes. Creatine cycling is important for thermogenesis and an altered creatine cycle could lead to obesity.
Enhancer of energy expenditure through stimulation of mitochondrial ATP turnover.

Product References

Creatine: endogenous metabolite, dietary, and therapeutic supplement: J.T. Brosnan & M.E. Brosnan; Annu. Rev. Nutr. 27, 241 (2007) (Review)
Creatine as an antioxidant: P. Sestili, et al.; Amino Acids 40, 1385 (2011) (Review)
Creatine inhibits adipogenesis by downregulating insulin-induced activation of the phosphatidylinositol 3-kinase signaling pathway: N. Lee, et al.; Stem Cells Dev. 24, 983 (2015)
Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity: L. Kazak, et al.; Cell Metab. 26, 660 (2017)
Creatine fuels the thermic effect of feeding: A.R. Saltiel; Cell Metab. 26, 594 (2017) (Review)
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease: M.J. Betz & S. Enerbaeck; Nat. Rev. Endocrinol. (Epub ahead of print) (2017) (Review)