Adipogen/Chetomin/BVT0161M001/1 mg

MoreInformation
ProductDetails
Synonyms	CTM;Chaetomin;NSC289491;BRN0077366
ProductType	Chemical
Properties
Formula	C₃₁H₃₀N₆O₆S₄
MW	710.9
CAS	1403-36-7
Source/HostChemicals	IsolatedfromChaetomiumsp.
PurityChemicals	≥98%(HPLC)
Appearance	Off-whitetofawnsolid.
Solubility	SolubleinDMSO,ethylacetateorpyridine;fairlysolubleinmethanolor100%ethanol;insolubleinwater.
Identity	Determinedby¹H-NMR.
Declaration	ManufacturedbyBioViotica.
InChiKey	ZRZWBWPDBOVIGQ-OKMJTBRXSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
HandlingAdvice	Protectfrommoisture. Protectfromlightwheninsolution.
Use/Stability	Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

ProductReferences

Thestructureofchetomin:A.G.McInnes,etal.;JACS98,6741(1976)
Effectsofchetominongrowthandacidicfermentationproductsofrumenbacteria:W.C.JenandG.A.Jones;Can.J.Microbiol.29,1399(1983)
ImmunomodulatoryconstituentsfromanAscomycete,Chaetomiumseminudum:H.Fujimoto,etal.;J.Nat.Prod.67,98(2004)
Smallmoleculeblockadeoftranscriptionalcoactivationofthehypoxia-induciblefactorpathway:A.L.Kung,etal.;CancerCell6,33(2004)
EffectsofHIF-1inhibitionbychetominonhypoxia-relatedtranscriptionandradiosensitivityinHT1080humanfibrosarcomacells:A.Staab,etal.;BMCCancer7,213(2007)
Epidithiodiketopiperazinesblocktheinteractionbetweenhypoxia-induciblefactor-1α(HIF-1α)andp300byazincejectionmechanism:K.M.Cook,etal.;J.Biol.Chem.284,26831(2009)
Directinhibitionofhypoxia-inducibletranscriptionfactorcomplexwithdesigneddimericepidithiodiketopiperazine:K.M.Wang,etal.;JACS131,18078(2009)
Up-regulationofpro-inflammatorygenesasadaptationtohypoxiainMCF-7cellsandinhumanmammaryinvasivecarcinomamicroenvironment:M.Tafani,etal.;CancerSci.101,1014(2010)
InhibitionofhistoneH3K9methyltransferasesbygliotoxinandrelatedepipolythiodioxopiperazines:M.Takahashi,etal.,J.Antibiot.65,263(2012)
Epidithiodiketopiperazines(ETPs)exhibitinvitroantiangiogenicandinvivoantitumoractivitybydisruptingtheHIF-1α/p300complexinapreclinicalmodelofprostatecancer:K.M.Reece,etal.;Mol.Cancer13, 91(2014)
Small-molecule–directed,efficientgenerationofretinalpigmentepitheliumfromhumanpluripotentstemcells:J.Maruotti,etal.;PNAS112,10950(2015)