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| Synonyms | Monoclonal CCM2 antibody, Anti-CCM2 antibody, Cerebral cavernous malformation 2 antibody, C7orf22 antibody, MGC4607 antibody, Cerebral cavernous malformations 2 protein antibody, MGC4067 antibody, Chromosome 7 open reading frame 22 antibody, Malcavernin antibody, CCM2, CCM 2, CCM-2, CCM 2 antibody, CCM-2 antibody |
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| Cross Reactivity | Human |
| Applications | IF, WB |
| Immunogen | CCM2 antibody was raised in mouse using a full length recombinant protein of human CCM2 (NP_113631) produced in HEK293T cells, as the immunogen. |
| Host | Mouse |
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| Clone | 3B7 |
| Isotype | IgG1 |
| Method of Purification | CCM2 antibody was purified by affinity chromatography. |
| Form & Buffer | Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 500 ug-1 mg/ml |
| Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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| Usage Recommendations | IF: 1:100, WB: 1:2000 |
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| Biological Significance | CCM2 is a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK)signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via aphosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. . |
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