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NSJ/Pan SUMO Antibody (F42636)/ F42636-0.4ML/ 0.4 ml188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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NSJ/Pan SUMO Antibody (F42636)/ F42636-0.4ML/ 0.4 ml

Formulation:

In 1X PBS, pH 7.4, with 0.09% sodium azide

Data:

Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt P55854
Applications IHC (Paraffin) : 1:50-1:100
Western blot : 1:1000
Limitations This Pan SUMO antibody is available for research use only.

Description:

Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1.

Application Notes:

Titration of the Pan SUMO antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen:

This pan SUMO antibody recognizes human SUMO1, SUMO2 and SUMO3; rabbits were immunized with a recombinant protein encoding full length human SUMO1.

Storage:

Aliquot the pan SUMO antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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