Deprecated: Creation of dynamic property cls_session::$session_data_table is deprecated in /www/sites/www.188bio.com/index/systems/cls_session.php on line 49
Lucerna/Diglycyl-Lysine Antibody, clone GX41 (100 µg)/30-0100/0100188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
您好,欢迎您进入188进口试剂采购网网站! 服务热线:4000-520-616
蚂蚁淘商城 | 现货促销 | 科研狗 | 生物在线
产品资料

Lucerna/Diglycyl-Lysine Antibody, clone GX41 (100 µg)/30-0100/0100

OTHERTOOLSANDRESOURCES 

 

 

 

REFERENCEFORTHEPRODUCT: 

 

Globalanalysisoflysineubiquitinationbyubiquitinremnantimmunoaffinityprofiling. XuG,PaigeJS,JaffreySR.NatureBiotechnology. 2010Aug;28(8)868-73.

 

 

THISPRODUCTWASCITEDIN: 

 

 

proteome-widequantitative survey ofinvivo ubiquitylation sites reveals widespread regulatory roles. WagnerSA, etal. Molecular&CellularProteomics. 2011Sep.  

  
Proteomicanalysesrevealdivergentubiquitylationsitepatternsinmurinetissues.WagnerSA,etal. Molecular&CellularProteomics.2012Jul.

 

Systems-wideanalysisofubiquitylationdynamicsrevealsakeyroleforPAF15ubiquitylationinDNA-damagebypass.PovlsenLK,etal. NatureCellBIOLOGy. 2012Sep.

 

 

 

SpeciesReactivity
KeyApplicationsHostFormatAntibodyType
Human,mouse,rat,chicken,yeast,cowhorseWB,IPMousePurifiedMonoclonalAntibody
 

 

DESCRIPTION:Anti-Diglycyl-lysineantibody,cloneGX41
 
SPECIFICITY:Antibodyrecognizeslysineresiduesmodifiedbydiglycine,anadductleftatsitesofubiquitinationaftertrypsindigest.
 
SOURCE/PURIFICATION:Monoclonalantibodiesareproducedbyimmunizinganimalswithasyntheticdiglycine-modifiedhistonepeptideandestablishedinhybridomalineGX41.AntibodiesarepurifiedbyproteinAandpeptideaffinitychromatography.
 
PRESENTATION:LysophilizedIgG
 
STORAGECONDITIONS:Stablefor2yearat-20ºC.
 

QUALITYASSURANCE:EachantibodybatchismeasuredforitsABIlitytobindtoproteinscontainingdiglycyl-lysineandtorecoverdiglycyl-lysine-containingpeptidesfromtrypticdigestsofHEK293cells.

 

USAGESTATEMENT:Thisproductisintendedforresearchuseonlyandarenottobeusedforanyotherpurpose,whichincludesbutisnotlimitedto,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticusesoranytypeofconsumptionorapplicationtohumansoranimals.Duetothehighlyspecificnatureofantibodiesandantigens,wecannotpredictorbeheldresponsIBLewithrespecttohowLucernaTMproductswillbehaveinitscustomers"systems.ResearchersusingLucernaTMproductsshouldconductoptimizationstudiestoachievetheoptimalresultpossiblefortheirintendedapplication.

 

LICENSING:CornellUniversityhasfiledausepatentonproteomicmethodsthatusethediglycyl-lysineantibodytoidentifyubiquitinatedproteins.Allcommercial usersshouldcontactCornellUniversityforauselicense.

 

GX41antibodyrecognizesthediglycyl-lysinemoietyatubiquitinatedsitesaftertrypsindigestion

 

 

Specificityofanti-diglycyl-lysine(cloneGX41)isverifiedbywesternblotanalysisofbeta-lactoglobulin,lysozyme,orratbrainlysate,inwhichthelysineswereeitherunmodified(A)ormodifiedwithGly-Gly(B),respectively. Asshownabove,theGX41exhibitsnodetectablereactivitywithproteinsunlessthelysinesaremodifiedwithGly-Gly.

 


 

Equimolaramountsofthetwopeptides(GGDRVYIHPFHLandAc-SYSMEHFRWGK*PV-NH2)wereimmunoprecipitatedwithimmobilizedGX41antibodyandanalyzedbyMALDI-TOFMS.K*referstoalysinewithaGly-Glymodification. Asshownabove,theunmodifiedpeptideisabsentfromtheimmunoprecipitate,whilethepeptidecontainingtheGly-Glymodificationisimmunoprecipitated.

 

新闻动态
行业前沿
技术文章
最新产品