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| Description |
Pepstatin is a potent inhibitor of aspartyl proteases, and inhibits the aspartic proteases cathepsin D, pepsin, and renin. |
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| In Vivo |
A low dose of pepstatin shows an inhibition of edema formation, and intraperitoneal injection of 1.25 mg/kg of pepstatin causes a 30% inhibition with a a very low toxicity[1]. Pepstatin increases LC3-II levels, while it is reverted by 3-methyladenine (3-MA)[2]. |
| References |
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| Preparing Stock Solutions |
Please refer to the solubility information to select the appropriate solvent.
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| References |
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| Molecular Weight |
685.89 |
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| Formula |
C₃₄H₆₃N₅O₉ |
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| CAS No. |
26305-03-3 |
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| Storage |
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| Shipping | Room temperature in continental US; may vary elsewhere |
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| Solvent & Solubility |
DMSO: ≥ 25 mg/mL
* "<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation=""> |
Purity: 98.45%
COA (94 KB) LCMS (1269 KB)
Handling Instructions (1252 KB)[1]. Umezawa H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo). 1970 May;23(5):259-62.
[2]. Raquel T. Lima, et al. Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells. Molecules 2016, 21(10), 1343
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