SPECIES: | Human |
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SOURCESPECIES: | E.coli |
SEQUENCE: | MKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH |
TESTEDAPPLICATIONS: |
PURITY: | Greaterthan90%bySDS-PAGEgelandHPLCanalyses. Endotoxinlevelislessthan0.1ngperμg(1EU/μg). |
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PHYSICALSTATE: | Lyophilized |
STORAGECONDITIONS: | ThelyophilizedApoE3recombinantproteinisstableforatleast2yearsfromdateofreceiptat-20˚C.ReconstitutedApoE3isstableforatleast3monthswhenstoredinworkingaliquotswithacarrierproteinat-20˚C.Aswithanyprotein,exposingApoE3recombinantproteintorepeatedfreeze/thawcyclesisnotrecommended.Whenworkingwithproteinscareshouldbetakentokeeprecombinantproteinatacoolandstabletemperature. |
ALTERNATENAMES: | AD2,LPG,LDLCQ5,ApolipoproteinE,Apo-E |
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ACCESSIONNO.: | NP_000032.1 |
PROTEINGINO.: | 4557325 |
ApoE3belongstoagroupofproteinsthatbindreversIBLywithlipoproteinandplayanimportantroleinlipidmetabolism.Inadditiontofacilitatingsolublizationoflipids,theseproteinshelptomaintainthestructuralintegrityoflipoproteins,serveasligandsforlipoproteinreceptors,andregulatetheactivityofenzymesinvolvedinlipidmetabolism.SignificantquantitiesofApoEareproducedinliverandbrainandtosomeextentinalmosteveryorgan.ApoEexistsinthreemajorisoforms;E2,E3,andE4,whichdifferfromoneanotherbyasingleamino-acidsubstitution.E3isthemostcommonisoformandispresentin40-90%ofthepopulation.RecombinanthumanApoE3isa34.4kDaproteincontaining300aminoacidresidues. |
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