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| SPECIESREACTIVITY: | Human |
|---|---|
| HOMOLOGY: | Predictedspeciesreactivitybasedonimmunogensequence:Bovine:(88%),Mouse:(78%),Rat:(78%) |
| TESTEDAPPLICATIONS: | ELISA,IF,IHC-P,WB |
| APPLICATIONS: | ACE2antibodycanbeusedforthedetectionofACE2byWesternblotat0.5to2μg/mL.Antibodycanalsobeusedforimmunohistochemistrystartingat2μg/mL.Forimmunofluorescencestartat10μg/mL. |
| USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher. |
| POSITIVECONTROL: | 1)Cat.No.1305-HumanKidneyTissueLysate |
| 2)Cat.No.1313-HumanTestisTissueLysate | |
| 3)Cat.No.10-401-HumanKidneyTissueSlide | |
| PREDICTEDMOLECULARWEIGHT: | Predicted:89kDa Observed:95kDa |
| SPECIFICITY: | Anti-ACE2hasnocrossresponsetoACE1. |
| IMMUNOGEN: | ACE2antibodywasraisedagainstasyntheticpeptidecorrespondingtoaminoacidsneartheC-terminusofhumanACE2. Theimmunogenislocatedwithinthelast50aminoacidsofACE2. |
| HOSTSPECIES: | Rabbit |
| PURIFICATION: | ACE2Antibodyisaffinitychromatographypurifiedviapeptidecolumn. |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | ACE2AntibodyissuppliedinPBScontaining0.02%sodiumazide. |
| CONCENTRATION: | 1mg/mL |
| STORAGECONDITIONS: | ACE2antibodycanbestoredat4˚Cforthreemonthsand-20˚C,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| ALTERNATENAMES: | ACE2Antibody:ACEH,Angiotensin-convertingenzyme2,ACE-relatedcarboxypeptidase,ACEH |
|---|---|
| ACCESSIONNO.: | NP_068576 |
| PROTEINGINO.: | 11225609 |
| OFFICIALSYMBOL: | ACE2 |
| GENEID: | 59272 |
| BACKGROUND: | ACE2Antibody:Angiotensin-convertingenzyme2(ACE2)playsacentralroleinvascular,renal,andmyocardialphysiology.IncontrasttoitshomologACE,ACE2expressionisrestrictedtoheart,kidney,andtestis.Recently.ACE2hasalsobeenshowntobeafunctionalreceptoroftheSARScoronavirus.ThenormalfunctionofACE2istoconverttheinactivevasoconstrictorangiotensinI(AngI)toAng1-9andtheactiveformAngIItoAng1-7,unlikeACE,whichconvertsAngItoAngII.Whiletheroleofthesevasoactivepeptidesisnotwellunderstood,lackofACE2expressioninace2-/ace2-miceleadstoseverelyreducedcardiaccontractility,indicatingitsimportanceinregulatingheartfunction. |
|---|---|
| REFERENCES: | 1)DonoghueM,HsiehF,BaronasE,etal.Anovelangiotensin-convertingenzyme-relatedcarboxypeptidase(ACE2)convertsangiotensionItoangiotension1-9.Circ.Res.2000;87:1-9. | 2)TipnisSR,HooperNM,HydeR,etal.Ahumanhomologofangiotensin-convertingenzyme.Cloningandfunctionalexpressionasacaptopril-insensitivecarboxypeptidase.JBiol.Chem.2000;275:33238-43. | 3)LiW,MooreMJ,VasilevaN,etal.Angiotensin-convertingenzyme2isafunctionalreceptorfortheSARScoronavirus.Nature2003;426:450-4. | 4)CrackowerMA,SaraoR,OuditGY,etal.Angiotensin-convertingenzyme2isanessentialregulatorofheartfunction.Nature2002;417:822-8. |
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