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Santa Cruz/3-Amino-1,2,4-triazole (CAS 61-82-5)/sc-202016

3-Amino-1,2,4-triazole(CAS61-82-5)

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备用名:Aminotriazole; Amitrole

应用；3-Amino-1,2,4-triazole is an irreversible catalase inhibitor

CAS号码:61-82-5

纯度:≥95%

分子量:84.08

分子式:C₂H₄N₄

Supplemental Information:This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

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介绍
技术信息
安全信息
安全技术说明书和分析证明书

3-Amino-1,2,4-triazole is a small molecule irreversible inhibitor of catalase, an enzyme responsible for converting cellular H₂O₂ into H₂O and O₂. Impeding the natural clearance of H₂O₂ from the cell by catalase has proven useful in studies investigating free radical-mediated damage of cardiac tissue in ischemia. 3-Amino-1,2,4-triazole also shows inhibition of imidazoleglycerol-phosphate dehydratase (HIS3) activity, which interrupts the biosynthesis of histidines. When 3-Amino-1,2,4-triazole is diazotized, the resulting 3-Diazo-1,2,4-triazole is shown to react specifically with tryptophan at acidic pH, presenting a method for determining the tryptophan content of proteins.

参考文献

1. DeTraglia, M.C., et al. 1979. Anal. Biochem. 99: 464-473. PMID: 574724 2. Brennan, M.B. and Struhl, K. 1980. J. Mol. Biol. 136: 333-338. PMID: 6990004 3. Kidd, G.L. and Gross, S.R. 1984. J. Bacteriol. 158: 121-127. PMID: 6325383 4. Aragon, C.M., et al. 1991. Biochem. Pharmacol. 42: 699-702. PMID: 1859472 5. Auyeung, Y., et al. 1995. Circulation. 92: 3318-3322. PMID: 7586320 6. Kingma, J.G., et al. 1996. Am. J. Physiol. 270: H1165-H1171. PMID: 8967353 7. Joung, J.K., et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 7382-7387. PMID: 10852947

物理状态:

Solid

溶解度:

Soluble in water (280 g/l) at 20° C, methanol, ethanol, chloroform, and ethyl acetate (slightly). Insoluble in ether, and acetone.

保存:

Store at 4° C

熔点:

150-153° C (lit.)

沸点:

322.2-373.2° C at 760 mmHg (Predicted)

密度:

~1.5 g/cm³ at 20° C

折射率:

n²⁰_D 1.67 (Predicted)

IC50:

Human immunodeficiency virus type 1 integrase: IC₅₀ = 170 nM (Human immunodeficiency virus 1)

Ki 数据:

Imidazolglycerol-phosphate dehydratase: K_i= 30 µM

pK值:

pK_b: 9.40

仅供科研使用。不可用于诊断或治疗。

德国水公害等级:

RTECS:

XZ3850000

PubChem CID:

1639

默克索引:

14: 489

MDL 号码:

MFCD00005230

EC号码:

200-521-5

Beilstein 注册:

107687

SMILES:

C1=NNC(=N1)N

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引用1 - 5 的 5

PMID: # 29363570Cao, Y. et al. 2018. Reproduction. 155: 307-319.

PMID: # 30014903Shen, M. et al. 2018. Redox Biol. 18: 138-157.

PMID: # 28330870Son, YO. et al. 2017. J. Biol. Chem. 292: 8315-8330.

PMID: # 25157103Son, YO. et al. 2014. J. Biol. Chem. 289: 28660-75.

PMID: # 32238563Proc. Natl. Acad. Sci. U.S.A.