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Santa Cruz/Phenylbutazone (CAS 50-33-9)/sc-204843

Phenylbutazone(CAS50-33-9)

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应用；Phenylbutazone is an inhibitor of Cox

CAS号码:50-33-9

纯度:≥99%

分子量:308.38

分子式:C₁₉H₂₀N₂O₂

Supplemental Information:This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

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介绍
技术信息
安全信息
安全技术说明书和分析证明书

Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.

参考文献

1. Takahashi, M., et al. 1990. Carcinogenesis. 11: 393-395. PMID: 2311181 2. Hixson, L.J., et al. 1994. Cancer Epidemiol. Biomarkers Prev. 3: 433-438. PMID: 7920212 3. Rainsford, K.D. 2007. Subcell. Biochem. 42: 3-27. PMID: 17612044

物理状态:

Solid

溶解度:

Soluble in water (1 mg/ml at 25° C), ethanol (62 mg/ml at 25° C), methanol, DMSO (62 mg/ml at 25° C), and DMF (25 mg/ml).

保存:

Store at room temperature

熔点:

106-108° C (lit.)

沸点:

~424.9° C at 760 mmHg (Predicted)

密度:

~1.2 g/cm³ (Predicted)

折射率:

n²⁰_D 1.59 (Predicted)

IC50:

Cox-1: IC₅₀ = 3 µM (human); Cyclooxygenase-2: IC₅₀ = 3.79 µM (Canis lupus familiaris); PGH synthase : IC₅₀ = 10 µM; Plasmodium falciparum 3D7: IC₅₀ = 10 µM; Plasmodium falciparum D10: IC₅₀ = 12.59 µM

Ki 数据:

CYP2C9: K_i= 19 µM (human); OAT3: K_i= 34.7 µM (human); AZT glucuronidation: K_i= 1.4 mM (human); Codeine glucuronidation: K_i= 1.7 mM

pK值:

pK_a: 4.64 (Predicted)

仅供科研使用。不可用于诊断或治疗。

德国水公害等级:

RTECS:

UQ8225000

PubChem CID:

4781

默克索引:

14: 7277

MDL 号码:

MFCD00005500

EC号码:

200-029-0

Beilstein 注册:

290080

SMILES:

CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

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PMID: # 21348489Mironov, GG. et al. 2011. Analytical chemistry. 83: 2364-70.