Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.
1. Takahashi, M., et al. 1990. Carcinogenesis. 11: 393-395. PMID: 2311181 2. Hixson, L.J., et al. 1994. Cancer Epidemiol. Biomarkers Prev. 3: 433-438. PMID: 7920212 3. Rainsford, K.D. 2007. Subcell. Biochem. 42: 3-27. PMID: 17612044
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PMID: # 21348489Mironov, GG. et al. 2011. Analytical chemistry. 83: 2364-70.
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