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Santa Cruz/Phenylbutazone (CAS 50-33-9)/sc-204843

Phenylbutazone(CAS50-33-9)

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应用;Phenylbutazone is an inhibitor of Cox
CAS号码:50-33-9
纯度:≥99%
分子量:308.38
分子式:C19H20N2O2
Supplemental Information:This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.

参考文献

1. Takahashi, M., et al. 1990. Carcinogenesis. 11: 393-395. PMID: 2311181 2. Hixson, L.J., et al. 1994. Cancer Epidemiol. Biomarkers Prev. 3: 433-438. PMID: 7920212 3. Rainsford, K.D. 2007. Subcell. Biochem. 42: 3-27. PMID: 17612044

物理状态:
Solid
溶解度:
Soluble in water (1 mg/ml at 25° C), ethanol (62 mg/ml at 25° C), methanol, DMSO (62 mg/ml at 25° C), and DMF (25 mg/ml).
保存:
Store at room temperature
熔点:
106-108° C (lit.)
沸点:
~424.9° C at 760 mmHg (Predicted)
密度:
~1.2 g/cm3 (Predicted)
折射率:
n20D 1.59 (Predicted)
IC50:
Cox-1: IC50 = 3 µM (human); Cyclooxygenase-2: IC50 = 3.79 µM (Canis lupus familiaris); PGH synthase : IC50 = 10 µM; Plasmodium falciparum 3D7: IC50 = 10 µM; Plasmodium falciparum D10: IC50 = 12.59 µM
Ki 数据:
CYP2C9: Ki= 19 µM (human); OAT3: Ki= 34.7 µM (human); AZT glucuronidation: Ki= 1.4 mM (human); Codeine glucuronidation: Ki= 1.7 mM
pK值:
pKa: 4.64 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级:
3
RTECS:
UQ8225000
PubChem CID:
4781
默克索引:
14: 7277
MDL 号码:
MFCD00005500
EC号码:
200-029-0
Beilstein 注册:
290080
SMILES:
CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

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PMID: # 21348489Mironov, GG. et al. 2011. Analytical chemistry. 83: 2364-70.

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