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| CatalogNumber: 21019 |
| GeneSymbol: CDC42 |
| Description: Anti-Cdc42ChickenPolyclonalAntibody |
| Background: SmallGTPasesareasuper-familyofcellularsignalingregulators.Cdc42belongstotheRhosub-familyofGTPasesthatregulatecellmotility,celldivision,andgenetranscription.GTPbindingincreasestheactivityofCdc42,andthehydrolysisofGTPtoGDPrendersitinactive.GTPhydrolysisisaidedbyGTPaseactivatingproteins(GAPs),whileexchangeofGDPforGTPisfacilitatedbyguaninenucleotideexchangefactors(GEFs). |
| Immunogen: RecombinantfulllengthCdc42protein |
| Applications: ELISA,WB,IHC |
| RecommendedDilutions: ELISA:1:100-1:5000WB:1:100-1:1000IHC:1:100-1:1000 |
| Concentration: 1mg/ml |
| Host: Chicken |
| Format: Liquid |
| Clonality: Polyclonal |
| Isotype: IgY |
| Purity: Purifiedfromeggyolk |
| Storagebuffer: |
| Preservative: no |
| Constituents: PBS(withoutMg2+andCa2+),pH7.4,150mMNaCl,50%glycerol |
| SpeciesReactivity: Cdc42antibodyrecognizesCdc42fromvertebrates. |
| StorageConditions: Storeat-20°C.Avoidfreeze/thawcycles |
DownloadDatasheet:  |
| Westernblot: |
 | WesternblotanalysisofCdc42proteins.HepGwhole-celllysatewasusedforWesternblotwiththechickenpolyclonalanti-Cdc42antibody(cat#21019). |
Publications:| 1. VibrioparahaemolyticusEffectorProteinsSuppressInflammasomeActivationbyInterferingwithHostAutophagySignaling PLoSPathog.2013Jan;9(1):e1003142 | 2. Interferongammainducesactinpolymerization,Rac1activationanddownregulatesphagocytosisinhumanmonocyticcells Cytokine.2012Jan;57(1):158-68 | 3. Invadopodiaandrolling-typemotilityarespecificfeaturesofhighlyinvasivep190bcr-ablleukemiccells EuropeanJournalofCellBIOLOGyVolume91,Issues11–12,November–December2012,Pages978–987 | 4. EpithelialjunctionformationrequiresconfinementofCdc42activitybyanovelSH3BP1complex JCellBiol.2012Aug20;198(4):677-93 | 5. PolarizedmigrationoflymphaticendothelialcellsiscriticallydependentonpodoplaninregulationofCdc42 AmJPhysiolLungCellMolPhysiol.2011Jan;300(1):L32-42 | 6. TheAarskog-ScottSyndromeProteinFgd1RegulatesPodosomeFormationandExtracellularMatrixRemodelinginTransformingGrowthFactorbeta-StimulatedAorticEndothelialCells MolCellBiol.2011Nov;31(22):4430-41 | 7. MMP-9andCXCL8/IL-8ArePotentialTherapeuticTargetsinEpidermolysisBullosaSimplex PLoSOne.2013Jul19;8(7):e70123 | 8. p21-ActivatedKinase(PAK)RegulatesCytoskeletalReorganizationandDirectionalMigrationinHumanNeutrophils PLoSOne.2013Sep3;8(9):e73063 | 9. TheCdc42GuanineNucleotideExchangeFactorFGD6CoordinatesCellPolarityandEndosomalMembraneRecyclinginOsteoclasts JBiolChem.2014Jun27;289(26):18347-59 | 10. Cdc42InhibitorandUsesThereof UnitedStatesPatentApplication20140194451 | 11. Theα4NicotinicReceptorPromotesCD4+T-CellProliferationandaHelperT-CellImmuneResponse MolecularPharmacologyJanuary2014vol.85no.150-61 |
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