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reprocell/Stemolecule ALK5 Inhibitor (RepSox)/04-0015-base

Stemolecule ALK5 Inhibitor, also known as RepSox, E 616452, and SJN 2511, is a selective and ATP-competitive inhibitor of the TGFβ family type I receptor activin receptor-like kinase (ALK5)1. The ALK5 Inhibitor works by preventing autophosphorylation of ALK5. It has also been shown that ALK5 can replace Sox2 when reprogramming cells to induced pluripotent stem (iPS) cells. Through inhibition of the TGFβ pathway, ALK5 works to reprogram cells that have been transduced with Oct4, Klf4, and c-Myc2. ALK5 Inhibitor promotes the differentiation of MYH11-positive cells by modulating NOTCH signaling4.

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