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reprocell/Stemolecule All-Trans Retinoic Acid/04-0021-base

Stemolecule All-Trans Retinoic Acid is the oxidized form of Vitamin A and functions as a signaling molecule for various developmental pathways that control differentiation and proliferation1,2. It acts by binding to heterodimers of the retinoic acid receptor (RAR) and the retinoid × receptor (RXR), which then bind to retinoic acid response elements (RAREs) in the regulatory regions activating gene transcription3. All-Trans Retinoic Acid has been implicated in specification of the embryonic anterior/posterior axis through Hox gene regulation4. It has been used in various differentiation protocols, including B-cells, T-cells and neurons and applied clinically to treat cancer as a form of differentiation-induction therapy2,5-11.

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