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reprocell/Stemolecule BIO/04-0003-base

BIO (6-bromoindirubin-3"-oxime) is a potent, reversible and ATP-competitive inhibitor for GSK-3α/β in the Wnt signaling pathway. BIO is the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells1. BIO-mediated activation of the Wnt signaling cascade maintained the undifferentiated state of both mouse and human embryonic stem cells under feeder free conditions possibly by Wnt-induced increase in the expression of Nodal2-4.

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