产品资料

Abeomics/Monoclonal Antibody to TLR6 (Clone: ABM1B50)/25 µg/10-3002

Format :	Purified
Amount :	100 µg
Isotype :	Mouse IgG1 Kappa
Purification :	Protein G Chromatography
Content :	25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	TLR6
Gene ID :	10333
Uniprot ID :	Q9Y2C9
Alternative Name :	TLR6
Immunogen Information :	A partial length recombinant TLR6 protein (amino acids 280-512) was used as the immunogen for this antibody.

TLR6 (Toll-Like Receptors 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 forms heterodimers with TLR1 and TLR2, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. TLR2 in co-operation with TLR6 trigger inflammatory responses via activation of NF-kappaB, which regulates the transcription of inflammatory molecules. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles)-induced inflammatory responses. Upon silencing, TLR6 significantly inhibited the pro-inflammatory cytokine levels, reactive nitrogen species generation and inducible nitric oxide synthase expression.

Western blot analysis: 2-4 µg/ml; FACS analysis:0.5-1 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cell membrane, Cytoplasmic vesicle, Membrane raft, Golgi apparatus
Tissue Specificity:	Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
BioGrid:	115616.3 interactions.

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