产品资料

Abeomics/Monoclonal Antibody to TLR9 (Clone: ABM1C51) PE conjugated/25 Test/10-3003-P

Format :	Purified
Amount :	100 Test
Isotype :	Mouse IgG1 Kappa
Purification :	Protein G Chromatography
Content :	0.04mg/ml in PBS with 0.05% Azide.
Storage condition :	Store the antibody at 4°C, stable for 6 months.


Gene :	TLR9
Gene ID :	54106
Uniprot ID :	Q9NR96
Alternative Name :	TLR9, UNQ5798/PRO19605
Immunogen Information :	A partial length recombinant TLR9 protein (amino acids 100-290) was used as the immunogen for the antibody.

TLR9, a member of toll-like receptor family are central to the innate immunity by identifying pathogen associated molecular patterns (PAMPs). TLR9 identify unmethylated CpG dinucleotides present in bacterial DNA leading to NF-kB activation.

FACS analysis: 0.5 -1 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Endoplasmic reticulum membrane, Endosome, Lysosome, Cytoplasmic vesicle
Post transnational modification:	Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.
Tissue Specificity:	Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
BioGrid:	119902.20 interactions.

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