产品资料

Abeomics/Recombinant Mouse Monoclonal Antibody to MART-1 / Melan-A / MLANA (Melanoma Marker)(Clone : rMLANA/788)/20 µg/12-1002

Format :	Purified
Amount :	100 µg
Isotype :	Mouse IgG1, kappa
Purification :	Purified Ab with BSA and Azide at 200ug/ml
Content :	200ug/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	MLANA
Gene ID :	2315
Uniprot ID :	Q16655
Alternative Name :	Antigen LB39-AA, Antigen SK29-AA, Melanoma antigen recognized by T-cells 1, MLAN-A, MLANA
Immunogen Information :	Recombinant full-length human MLANA protein

This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A.MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes.Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1.Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

MW : 20-22kDa (doublet); Positive Control : SK-MEL-13 and SK-MEL-19 Melanoma cell lines; Melanomas;Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (0.5-1ug/ml); Western Blotting (0.5-1.0ug/ml); Immunohistology (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Endoplasmic reticulum membrane, Golgi apparatus, Golgi apparatus, Melanosome
Post transnational modification:	Acylated.
Tissue Specificity:	Expression is restricted to melanoma and melanocyte cell lines and retina.
BioGrid:	108604.2 interactions.

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