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GloboZymes AK/PAK2 Detection Kit includes 200 μg of affinity-purified Anti-AK/PAK2 and a sample of highly purified AK/PAK2. The AK/PAK2 sample is provided in SDS sample buffer ready for use in five applications as positive control in Western blots. The polyclonal antibody was produced in rabbits to a synthetic peptide corresponding to residues 273-291 of the catalytic domain of human lymphocyte PAK2.
Synonyms: p21-Activated Protein Kinase PAK2 Catalytic Domain Western Blot Detection Kit.
Background: The catalytic domain of PAK2 was originally isolated as an Auto-activated Protein Kinase (AK). It was so termed because the purified enzyme underwent rapid autophosphorylation and concomitant 15-30-fold activation. Subsequent identification of PAK’s and amino sequencing of AK revealed that it was equivalent to the catalytic domain of PAK2*. Unlike native PAK2, AK does not require the p21-GTPases Cdc42 and Rac for activity. AK is a physiologically relevant form of PAK2. It is produced from the native enzyme via a caspase-dependent pathway in cells undergoing apoptosis.
References: Proc Natl Acad Sci USA 90: 2500 J Biol Chem 268: 11193 J Cell Physiol 178: 397 J Biol Chem 276: 14909 * Damuni Z. unpublished observations
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