产品资料

immusmol/D-Serine antibody - Rabbit polyclonal Ab/50µL (approx. 40 tissue sections)/IS1004

Product overview

Product name	D-Serine antibody - Rabbit pAb
Synonyms	Anti-D-Serine antibodyAnti (R)-Serine antibody
Immunogen	Conjugated D-Serine
Specificity	When tested in competitive ELISA, the anti-conjugated D-Serine antibody did not show any significant cross reactivity with D-Serine analogs, including L-Serine and D-Threonine.
Lot number	140301

Storage

Form	Liquid
Purity	Purified anti-serum
Storage buffer	Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles.
Material safety datasheet	Download MSDS

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Protocols

IF - Cell cultures, Whole mounts, Tissue sections	Dilute antibody with the antibody diluent provided in the STAINperfect immunostaining kit A. Use at 1/250 -1/1000 dilution. Follow the STAINperfect protocol suited to your sample
Comments	Optimal working dilutions must be determined by the end-user
Restrictions	For research use only
Full protocol	Download STAINperfect protocol for D-Serine staining
Protocols-at-a-glance


Complete Instructions for Use	Protocol-at-a-glance for cell cultures	Protocol-at-a-glance for whole mounts	Protocol-at-a-glance for tissue sections

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References

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Selected publications on D-Serine:

Paul P, de Belleroche J. The role of D-serine and glycine as co-agonists of NMDA receptors in motor neuron degeneration and amyotrophic lateral sclerosis (ALS). Front Synaptic Neurosci. 2014 Apr 16;6:10.
Balu DT et al. D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain. Cell Mol Neurobiol. 2014 Apr;34(3):419-35. doi: 10.1007/s10571-014-0027-z. Epub 2014 Jan 17.
Klatte K et al. Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy. J Neurosci. 2013 Aug 7;33(32):13066-80.
Otte DM et al. Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. PLoS One. 2013 Jun 21;8(6):e67131.
Martineau M et al. Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. J Neurosci. 2013 Feb 20;33(8):3413-23. doi: 10.1523/JNEUROSCI.3497-12.2013.
Van Horn MR, Sild M, Ruthazer ES. D-serine as a gliotransmitter and its roles in brain development and disease. Front Cell Neurosci. 2013 Apr 23;7:39. doi: 10.3389/fncel.2013.00039.

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