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| AlternativeName: | Synaptobrevin,Vesicle-associatedmembraneprotein2 |
| Host: | Rabbit |
| Immunogen: | SyntheticpeptidecorrespondingtoaportionofratVAMP2.Thesequenceiscompletelyconservedinmouse,human,bovine,andXenopus. |
| UniProtID: | P63045 |
| GenBankID: | M24105 |
| Speciesreactivity: | Human,Mouse,Rat Bovine,Guineapig,Rabbit |
| Applications: | ICC,IP,WB |
| RecommendedDilutions/Conditions: | WesternBlot(1:1,000,ECL) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| ApplicationNotes: | Detectsabandof~18kDabyWesternblot. |
| PurityDetail: | ProteinAaffinitypurified. |
| Formulation: | Liquid.InPBS,pH7.2,containing50%glyceroland0.09%sodiumazide. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | -20°C |
| ScientificBackground: | Vesicle-associatedmembraneprotein(VAMP),alsoknownassynaptobrevin,isan18kDaintegralmembraneproteinlocalizedtothecytoplasmicsurfaceofsynapticvesicles.TwoVAMPhomologs,VAMP1andVAMP2,aredifferentiallyexpressedinthenervoussystem.VAMP2isfoundinneuronsassociatedwithautonomic,sensoryandintegrativefunctions,andinnon-neuronalLangerhansisletsandglomerularcells.VAMPisacomponentofa20Scompleximplicatedinvesicledockingandfusion,theformationofwhichinvolvestheinteractionofVAMPwithsyntaxinthroughanATP-dependentreactionmodulatedbysynaptotagmin,SNAP-25,alpha-SNAP,andNSF. |