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| AlternativeName: | SKB,PRDM1 |
| Host: | Rabbit |
| Immunogen: | SyntheticpeptidecorrespondingtoaportionofhumanPRMT1. |
| UniProtID: | Q99873 |
| Speciesreactivity: | Human |
| Applications: | ELISA,IHC,WB |
| RecommendedDilutions/Conditions: | ELISA(1:1,000) Immunohistochemistry(1:50-1:100) WesternBlot(1:100-1:500) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| PurityDetail: | ProteinGaffinitypurified. |
| Formulation: | Liquid.InPBScontaining0.09%sodiumazide. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | -20°C |
| ScientificBackground: | ProteinarginineN-methyltransferases(PRMTs)catalyzethetransferofamethylgroupfromS-adenosylmethionine(AdoMet)toaguanidinenitrogenofarginine.PRMT1methylatesarginineresiduesinglycine-richareasofhistoneH4aswellasmanynon-histonesubstratesthatregulatetranscriptionalactivation,mRNAprocessing,andsignaltransduction.Incontrast,PRMT5methylatesargininesinproline-,glycine-,methionine-richmotifsandisknowntointeractwithJakkinases.PRMT2inhibitsNF-κB-dependenttranscriptionandpromotesapoptosis. |