企业QQ
官方微信
| AlternativeName: | B-lymphocyteantigenCD20 |
| Clone: | rIGEL/773 |
| Host: | Mouse |
| Isotype: | lgG2aκ |
| Immunogen: | RecombinantfulllengthhumanCD20. |
| UniProtID: | P11836 |
| Speciesreactivity: | Human |
| Applications: | FlowCytometry,IF,IHC(PS) |
| RecommendedDilutions/Conditions: | FlowCytometry(0.5-1µg/106cellsin0.1mL) Immunofluorescence(0.5-1µg/mL) Immunohistochemistry(formalin-fixedparaffinsections)(0.5-1µg/mL)for30minutesatRT Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| ApplicationNotes: | ThismAbcanbeusedforimmunophenotypingofleukemiaandmalignantcells,BlymphocytedetectioninperipheralbloodandBcelllocalizationintissues. |
| PurityDetail: | ProteinGaffinitypurified. |
| Formulation: | Liquid.In1XPBScontaining0.1mg/mlBSA(USsourced)and0.05%sodiumazide. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | +4°C |
| ScientificBackground: | CD20isexpressedbypreB-cellsandpersistsduringallstagesofB-cellmaturationbutislostuponterminaldifferentiationintoplasmacells.ItreactswiththemajorityofB-cellspresentinperipheralbloodandlymphoidtissuesandtheirderivedlymphomas.Inlymphoidtissue,germinalcenterblastsandB-immunoblastsareparticularlyreactive.ItisareliableantibodyforascribingaB-cellphenotypeinknownlymphoidtissues.Rarely,CD20-positiveT-celllymphomashavebeenreported.ReactivityhasalsobeennotedwithReed-SternbergcellsincasesofHodgkinsdisease,particularlyoflymphocytepredominanttype. |