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| AlternativeName: | NEFH,NF-H |
| Host: | Rabbit |
| Immunogen: | NativebovineNeurofilamentNF-H. |
| UniProtID: | P12036(human) |
| Speciesreactivity: | Human,Mouse,Rat |
| Applications: | ICC,WB |
| RecommendedDilutions/Conditions: | Immunocytochemistry(1:100-1:500) WesternBlot(1:1,000-1:2500) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| ApplicationNotes: | Detectsabandof~200-220kDabyWesternblot. |
| Formulation: | Liquid.Wholerabbitantiserumcontaining50%glycerol,0.01%sodiumazide,and1.0mg/mlBSA. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | -20°C |
| ScientificBackground: | Neuron-specificneurofilamentsbelongtotheintermediatefilamentproteinfamily,alsoknownas10nmfilaments.Asmajorconstituentsoftheaxonalcytoskeleton,neurofilamentscontainheteropolymersofthreemajorproteins:200kDaheavymolecularweightproteinNF-H,160kDamediummolecularweightproteinNF-M,and68kDalightmolecularweightproteinNF-L,withtheratioofeachchangingduringneuronaldevelopment.Allthreeproteinscontainglobularheadandtaildomainsflankingacentralalpha-helicaldomain.Anaccumulationofneurofilamentproteinsand/ormutationsinoneofthethreemajorproteinsoccurduringtheprogressionofnumerousneurologicaldiseases,includingALS. |