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| AlternativeName: | HMOX1,Hsp32,Heatshockprotein32,Hemeoxygenase1 |
| Clone: | HO-1-2 |
| Host: | Mouse |
| Isotype: | IgG2b |
| Immunogen: | NativeratHO-1. |
| UniProtID: | P06762 |
| GenBankID: | J02722 |
| Speciesreactivity: | Human,Mouse,Rat Dog,Guineapig,Hamster,Monkey,Porcine,Rabbit |
| Applications: | FlowCytometry |
| RecommendedDilutions/Conditions: | FlowCytometry(1:100) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| PurityDetail: | ProteinGaffinitypurified. |
| Formulation: | Liquid.InPBScontaining0.09%sodiumazide. |
| Shipping: | BlueIceNotFrozen |
| LongTermStorage: | +4°C |
| ScientificBackground: | HemeOxygenase-1(HO-1)alsoknownasHsp32,istheinducibleisoformofhemeoxygenasethatcatalyzestheNADPH,oxygen,andcytochromeP450reductasedependentoxidationofhemetocarbonmonoxide,ferrousironandbiliverdinwhichisrapidlyreducedtobilirubin.TheseproductsoftheHOreactionhaveimportantphysiologicaleffects:carbonmonoxideisapotentvasodilatorandhasbeenimplicatedtobeaphysiologicalregulatorofcGMPandvasculartone;biliverdinanditsproductbilirubinarepotentantioxidants;"free"ironincreasesoxidativestressandregulatestheexpressionofmanymRNAs(e.g.,DCT-1,ferritinandtransferringreceptor)byaffectingtheconformationofironregulatoryprotein(IRP)-1anditsbindingtoironregulatoryelements(IREs)inthe5-or3-UTRsofthemRNAs.Todate,threeidentifiedhemeoxygenaseisoformsarepartoftheHOsystemthatcatalyzehemeintobiliverdinandcarbonmonoxide.TheseareinducibleHO-1orHsp32,constitutiveHO-2thatisabundantinthebrainandtestis,andHO-3whichisrelatedtoHO-2butistheproductofadifferentgene.TheHOsystemistherate-limitingstepinhemedegradationandHOactivitydecreasesthelevelsofhemewhichisawellknownpotentcatalystoflipidperoxidationandoxygenradicalformation. |