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| AlternativeName: | ProstaglandinE2 |
| Clone: | BG8 |
| Host: | Mouse |
| Immunogen: | PGE2. |
| Speciesreactivity: | Speciesindependent |
| Applications: | ELISA |
| PurityDetail: | Ascites. |
| Formulation: | Liquid.Neatasciteswith0.09%sodiumazide. |
| Handling: | Avoidfreeze/thawcycles. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | -20°C |
| ScientificBackground: | ProstaglandinE2(PGE2)isanextensivelystudiedprostaglandinowingtoitspredominanceininflammation,cancer,atherosclerosis,autoimmunedisease,andsepsis.Oxidationofarachidonicacidbyprostaglandinsynthases(COX-1andCOX-2)producesprostaglandinH2(PGH2),whichisfurthermetabolizedbyPGEsynthasesintoitsmajorproduct,PGE2.PGE2mediatesautocrineandparacrinesignalingbybindingtoG-proteincoupledreceptors(EP1,EP2,EP3,EP4)onthecellsurface,functioningtomodulatephospholipaseCandadenylatecyclaseactivity.PGE2hasbeenofgreatinterestasatherapeutictarget,eitherbymodulationofitssynthesisbyCOXinhibitors(NSAIDS)orbymodulationofitsreceptorsbydownregulationorbindingantagonists.PGE2productioninavarietyoftissueshasbeenshowntomodulatenumerousphysiologicalprocessesincludingnatriuresisinthekidney,smoothmuscleelasticityinthevasculature,andtheinflammatoryresponsetodamagedtissuesbymonocytesandmacrophages. |