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| AlternativeName: | WilmsTumor1 |
| Clone: | WT1/1434R |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | RecombinantfulllengthhumanWT1. |
| UniProtID: | P19544 |
| Speciesreactivity: | Human |
| Applications: | FlowCytometry,IF,IHC(PS) |
| RecommendedDilutions/Conditions: | FlowCytometry(0.5-1µg/106cellsin0.1mL) Immunofluorescence(0.5-1µg/mL) Immunohistochemistry(formalin-fixedparaffinsections)(0.5-1µg/mLfor30minatRT) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| PurityDetail: | ProteinAaffinitypurified. |
| Formulation: | Liquid.In1XPBScontaining0.1mg/mlBSA(USsourced)and0.05%sodiumazide. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | +4°C |
| ScientificBackground: | WilmstumorisassociatedwithmutationsofWT1,azinc-fingertranscriptionfactorthatisessentialforthedevelopmentofthemetanephrickidneyandtheurogenitalsystem.Thegeneisnormallyexpressedinfetalkidneyandmesothelium,anditsexpressionhasbeensuggestedasaMarkerforWilmstumorandmesothelioma.WT1proteinhasbeenidentifiedinproliferativemesothelialcells,malignantmesothelioma,ovariancarcinoma,gonadoblastoma,nephroblastoma,anddesmoplasticsmallroundcelltumor.Lungadenocarcinomasrarelystainpositivewiththisantibody.WT1proteinexpressioninmesothelialcellshasbecomeareliablemarkerforthediagnosisofmesotheliomas. |