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| AlternativeName: | Ki-1,TNFRSF8 |
| Clone: | rKi-1/779 |
| Host: | Mouse |
| Isotype: | lgG1κ |
| Immunogen: | RecombinantfulllengthhumanCD30. |
| UniProtID: | P28908 |
| Speciesreactivity: | Human |
| Applications: | FlowCytometry,IF,IHC(PS) |
| RecommendedDilutions/Conditions: | FlowCytometry(0.5-1µg/106cellsin0.1mL) Immunofluorescence(1-2µg/mL) Immunohistochemistry(formalin-fixedparaffinsections)(0.5-1µg/mLfor30minatRT) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| ApplicationNotes: | ThismAbdistinguisheslargecelllymphomasderivedfromactivatedlymphoidcellsfromhistiocyticmalignanciesandlymphomasderivedfromrestingandprecursorlymphoidcellsorfromanaplasticcarcinomas. |
| PurityDetail: | ProteinGaffinitypurified. |
| Formulation: | Liquid.In1XPBScontaining0.1mg/mlBSA(USsourced)and0.05%sodiumazide. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | +4°C |
| ScientificBackground: | CD30issynthesizedasa90kDaprecursor,whichisprocessedintheGolgicomplexintoamembrane-boundphosphorylatedmature105/120kDaglycoprotein.InHodgkinsdisease,CD30/Ki-1antigenisexpressedbymononuclear-HodgkinandmultinucleatedReed-Sternbergcells.ItisalsoexpressedbythetumorcellsofamajorityofanaplasticlargecelllymphomasaswellasbyavaryingproportionofactivatedTandBcells.AboutonethirdoftheCD30/Ki-1positivelymphomaslacktheleukocytecommonantigen(CD45). |