| AlternativeName: | CRYAB,HSPB5 |
| Host: | Rabbit |
| Immunogen: | SyntheticpeptidecorrespondingtothesequenceneartheC-terminusofhumanαB-Crystallin.Thesequenceiscompletelyconservedinrat,rabbit,andbovine. |
| UniProtID: | P02511 |
| GenBankID: | M28638 |
| Speciesreactivity: | Human,Mouse,Rat Bovine,Porcine |
| Applications: | IF,IHC(PS),WB |
| RecommendedDilutions/Conditions: | WesternBlot(1:1,000,colorimetric) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| ApplicationNotes: | Detectsabandof~20kDabyWesternblot. |
| PurityDetail: | ProteinAaffinitypurified. |
| Formulation: | Liquid.InPBS,pH7.2,containing50%glyceroland0.09%sodiumazide. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | -20°C |
| ScientificBackground: | Alpha-crystallins,whicharepartofthesmallHeatshockfamilymembers,aremajorwater-solubleproteinspresentinthelensofthemammalianeye.Phosphorylationofserineresidueswhichoccursduringdevelopmentandinresponsetostress,isintimatelylinkedwithitsfunction.Chaperoneactivityrequires,andismodulatedby,oligomerizationandislimitedtobindingunfoldedintermediatestopreventirreversibleaggregation. |