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| AlternativeName: | CGRP |
| Host: | Sheep |
| Immunogen: | Syntheticpeptidecorrespondingtoaportionofratα-calcitoningene-relatedpeptide(CGRP). |
| UniProtID: | P01256 |
| Speciesreactivity: | Human,Mouse,Rat Rabbit |
| Crossreactivity: | Likelytoreactwithothermammalienspecies(basedonhomology,nottested). |
| Applications: | IHC |
| PurityDetail: | Ammoniumsulphateprecipitation. |
| Formulation: | Liquid.InPBScontaining0.1%sodiumazide. |
| Handling: | Avoidfreeze/thawcycles. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | -20°C |
| ScientificBackground: | Calcitoningene-relatedpeptide(CGRP)isa37-aminoaciddisulphide-bridgedsensoryneuropeptidepresentinthecentralandperipheralnervoussystemsofmanyanimalspecies.TwoformsofCGRP(αandβ)havebeenidentifiedfrombothratandhuman,andthesequenceofchickenCGRPhasalsobeenreported,showingstrikingstructuralsimilaritytothemammalianforms.CGRPisabundantinperivascularsensoryneuronsandisknowntobeapotentvasodilator.RecentworksupportstherôleofCGRPinmediatingskinvasodilatationanddifferentialmesentericarteryvasorelaxation,aswellasservingasanendogenousmyocardialprotectivesubstancewithapossibleinvolvementintheinhibitionofhumanplateletaggregation.CGRPisfrequentlyco-localisedwithSubstancePandimmunoelectronmicroscopicobservationshaveshownthatthepeptidesareco-storedinsinglesecretorygranulesbothinsensoryneuronsandinthyroidC-cells.Therearemanyhundredsofreportsinthescientificliteraturedescribingthelocalisationandco-existenceofCGRPwithothertransmittermoleculesinavastarrayofmammalianandnon-mammalianspecies. |
| TechnicalInfo/ProductNotes: | ApplicationDatadetails. Testtissues:Ratthoracolumbarspinalcord. Fixatives:Recommendedfixativeis4%formaldehyde(preparedfrompara-polymer)in0.1Msodiumphosphatebuffer(pH7.2-7.4).Perfusionfixationisrecommendedifpossible. |