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| AlternativeName: | Leucine-richrepeatkinase2,RIP7,PARK8,Dardarin |
| Host: | Rabbit |
| Immunogen: | RecombinanthumanLRRK2(leucine-richrepeatkinase2)(aa1838-2133). |
| UniProtID: | Q5S007 |
| Speciesreactivity: | Human |
| Specificity: | ThestrongestrecognizedepitopeisPDQPRLTIPISQ(aa1843-1854)asdefinedbyepitopemapping. |
| Applications: | IHC(PS),IP,WB |
| RecommendedDilutions/Conditions: | Immunohistochemistry(paraffinsections,1:500) Immunoprecipitation(1:100) WesternBlot(1:1,000) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| PurityDetail: | ProteinA-affinitypurified. |
| Formulation: | Liquid.InPBScontaining0.02%sodiumazide. |
| Handling: | Avoidfreeze/thawcycles.Afteropening,preparealiquotsandstoreat-20°C. |
| Shipping: | ShippedonBlueIce |
| ShortTermStorage: | +4°C |
| LongTermStorage: | -20°C |
| ScientificBackground: | LRRK2isalargeproteinwithmultipledomainsincludingseveralankyrin,leucine-rich,andWD40repeats,aRas-likesmallGTPasefamilydomainnamedRoc,andakinasedomainthatiscloselyrelatedtotheRIPkinasedomain.LRRK2geneisexpressedinbrainaswellasinothertissuessuchaslung,liverandheart.LRRK2mightbecentraltothepathogenesisofseveralmajorneurodegenerativediseasesassociatedwithparkinsonism.SeveraldominantlyinheritedmissensemutationsinthegeneencodingLRRK2havebeenidentifiedinseveralfamiliesthatexhibitabroadspectrumofneuropathologicalfeatures. |