Biological ActivityCB
2 antagonist/inverse agonist (K
i = 31.2 nM) that displays 165-fold selectivity over CB
1 receptors. Behaves as a weak partial/inverse agonist at CB
1 receptors.
Technical Data
M.Wt:
504.37
Formula:
C23H25IN2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98%
Storage:
Desiccate at +4°C
CAS No:
164178-33-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
- Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630.
Ross et al.
Br.J.Pharmacol., 1999;126:665 - AM630 antagonism of cannabinoid-stimulated [35S]GTPγS binding in the mouse brain.
Hosohata et al.
Eur.J.Pharmacol., 1997;321:R1 - AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain.
Hosohata et al.
Life Sci., 1997;61:PL115 - AM630 is an inverse agonist at the human cannabinoid CB1 receptor.
Landsman et al.
Life Sci., 1998;62:PL109
