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Tocris/VU 0469650 hydrochloride/5379/10/10 mg
Description:PotentandselectivenegativeallostericmodulatorofmGlu1
ChemicalName:3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrilehydrochloride
Purity:≥98%(HPLC)
BiologicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectivenegativeallostericmodulatorofmGlu1(IC50=99nM).Exhibits>100-foldselectivityformGlu1overmGlu2-8and68otherGPCRs,ionchannels,kinasesandtransporters.Brainpenetrant.

TechnicalData

M.Wt400.94
FormulaC22H28N4O.HCl
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1443748-47-7
PubChemID71680759
InChIKeyYENVAZRENOYZGQ-GUIQYPADSA-N
SmilesO=C(N4CCN(C5=C(C#N)N=CC=C5)C[C@H]4C)C12CC(C3)CC(CC3C2)C1.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO40.09100
ethanol20.0550

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight400.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.49mL12.47mL24.94mL
5mM0.5mL2.49mL4.99mL
10mM0.25mL1.25mL2.49mL
50mM0.05mL0.25mL0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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