CRSP1 Supplier | CAS 697327121 | Calcitonin ReceptorStimulating Peptide1 | Tocris Bioscience

生物活性

Endogenouscentralcalcitonin(CT)receptoragonistthatstimulatescAMPformationatapotency350-foldgreaterthanCT(ED50valuesare0.2and71nMrespectively).Displaysnoactivityatcalcitonin-generelatedpeptide(CGRP)andadrenomedullinreceptors.InhibitsformationofmultinuclearosteoclastswithsimilarefficacytoCTinvitro.Suppressesfoodintakeandincreasesbodytemperatureinfree-feedingrats,andsignificantlydecreasesplasmacalciumlevelsinvivo.

SCNTATCMTHRLVGLLSRSGSMVRSNLLPTKMGFKVFG

(Modifications:Disulfidebridgebetween2-7,Gly-38=C-terminalamide)

[H]N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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关键词:CRSP-1,CRSP-1supplier,Endogenous,central,CT,receptors,calcitonin,agonists,Calcitonin,receptor,stimulating,peptide1,receptor-stimulating,peptide-1,and,Related,Receptors,3555,TocrisBioscience

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