Displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for NR2A, NR2B, NR2C and NR2D subunits respectively).
Potentiates the steriodogenic(类固醇生成) action of corticotrophin on the adrenal cortex(肾上腺皮质), possibly via the MC3 receptor. Potently stimulates lipolysis(脂解) via activation of hormone-sensitive lipase (HSL)(脂肪酶).
Potent, endogenous NMU1 and NMU2 agonist:神经调节肽U受体激活剂
3648 | Neuromedin S (rat)神经调节肽
EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively. Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent endogenous anorexigenic peptide