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Tocris/Temozolomide/2706/50/50 mg
Description:DNA-methylatingantitumoragent
AlternativeNames:NSC362856,CCRG81045
ChemicalName:3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DNAmethylating,chemotherapeuticagent.Displaysantitumoractivityagainstaboardspectrumoftumors,includingleukemias,lymphomasandsolidtumors(IC50=5.0μMforcytotoxicityagainstmouseTLX5lymphomacells).Inducesautophagyinmalignantgliomacells.ExhibitsenhancedactivitywhenusedincombinationwithCHC(CatNo.5029).

CompoundLibraries

TemozolomideisalsoofferedaspartoftheTocriscreenPlus,TocriscreenEpigeneticsToolboxandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt194.15
FormulaC6H6N6O2
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber85622-93-1
PubChemID5394
InChIKeyBPEGJWRSRHCHSN-UHFFFAOYSA-N
SmilesCN1N=NC2=C(N=CN2C1=O)C(N)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO9.7150

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight194.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM5.15mL25.75mL51.51mL
5mM1.03mL5.15mL10.3mL
10mM0.52mL2.58mL5.15mL
50mM0.1mL0.52mL1.03mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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