Tocris/RS 102895 hydrochloride/2089/50/50 mg

Description:CCR2bchemokinereceptorantagonist

ChemicalName:1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-onehydrochloride

Purity:≥99%(HPLC)

BiologicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

CCR2-selectivechemokinereceptorantagonist(IC₅₀valuesare0.36and17.8μMforinhibitionofhumanrecombinantCCR2bandCCR1receptorsrespectively).BlocksMCP-1-stimulatedcalciuminfluxandchemotaxiswithIC₅₀valuesof32nMand1.7μMrespectively.Alsoinhibitsα_1A,α_1Dand5-HT_1Areceptors.

CompoundLibraries

RS102895hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	426.86
Formula	C₂₁H₂₁F₃N₂O₂.HCl
Storage	DesiccateatRT
Purity	≥99%(HPLC)
CASNumber	1173022-16-6
PubChemID	16759153
InChIKey	KRRISOFSWVKYBF-UHFFFAOYSA-N
Smiles	Cl.FC(F)(F)C1=CC=C(CCN2CCC3(CC2)OC(=O)NC2=CC=CC=C32)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	32.01	75

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight426.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.34mL	11.71mL	23.43mL
5mM	0.47mL	2.34mL	4.69mL
10mM	0.23mL	1.17mL	2.34mL
50mM	0.05mL	0.23mL	0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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